SJ 172550A MDMX inhibitor that inhibits MDMX-p53 interaction in cultured cells

SJ 172550 (CAS 431979-47-4)

SJ 172550 | CAS 431979-47-4 is rated 5.0 out of 5 by 1.
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Synonym: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid methyl ester
Application: A MDMX inhibitor that inhibits MDMX-p53 interaction in cultured cells
CAS Number: 431979-47-4
Purity: ≥95%
Molecular Weight: 428.87
Molecular Formula: C22H21ClN2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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SJ 172550 is an MDMX inhibitor which reversibly binds MDMX and inhibits MDMX-p53 interaction in cell cultures. Additionaly reported to induce apoptosis via liberation of p53.


References

1. Reed, D., et al. 2010. J. Biol. Chem. 285: 10786-10796. PMID: 20080970

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (≥30 mg/ml ).
Storage :
Store at 4° C
Melting Point :
238.65 °C (Predicted)
Boiling Point :
~560.8 °C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
MDMX: EC5050 = 2.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1317464
MDL Number :
MFCD03142926
SMILES :
CCOC1=C(C(=CC(=C1)/C=C/2C(=NN(C2=O)C3=CC=CC=C3)C)Cl)OCC(=O)OC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Reed et al Reed et al. (PubMed ID 20080970) found that SJ-172550 reversibly inhibited MDMX and killed retinoblastoma cells with elevated MDMX expression. -SCBT Publication Review
Date published: 2015-06-30
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