Sivelestat sodium tetrahydrate CAS: 201677-61-4
MF: C20H21N2O7S•Na•4H2O
MW: 528.51
An inhibitor of neutrophil elastase.

Sivelestat sodium tetrahydrate (CAS 201677-61-4)

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Alternate Names: Elaspol sodium salt tetrahydrate
Application: Sivelestat sodium tetrahydrate is an inhibitor of neutrophil elastase
CAS Number: 201677-61-4
Purity: ≥98%
Molecular Weight: 528.51
Molecular Formula: C20H21N2O7S•Na•4H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase (HNE) (IC50 = 44 nM, Ki = 0.2 µM). Sivelestat sodium tetrahydrate also effectively inhibits leukocyte elastase derived from hamster, mouse, rabbit and rat (IC50 = 19 to 49 nM). Sivelestat sodium tetrahydrate, even at concentrations of 100 µM, does not inhibit plasma kallikrein, plasmin, thrombin, trypsin, pancreas kallikrein, chymotrypsin and cathepsin G. In in-vivo studies, sivelestat sodium tetrahydrate suppressed lung hemorrhage in hamster (ID50 = 82 µg/kg) by intratracheal administration and increased skin capillary permeability in guinea pigs (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.


References

Shimoda, M. et al.,, Protective effect of Sivelestat in a porcine hepatectomy model prepared using an intermittent Pringle method. Eur. J. Pharmacol. 587, 248-252, (2008); Maeda, Y. et al.,, Sivelestat Relaxes Porcine Coronary Artery via Inhibition of Ca2+ Sensitization Induced by a Receptor Agonist. J. Cardiovasc. Pharmacol. 51, 476-482, (2008); Kono, T. et al.,, Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol. Cell Biochem. 311, 87-92, (2008)

Physical State :
Solid
Solubility :
Soluble in Water: >20 mg/mL
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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