Sivelestat (CAS 127373-66-4)

5.0(1)

Write a review Ask a question

See product citations (2)

Alternate Names: Elastase Inhibitor IV

Application: Sivelestat is an inhibitor of elastase

CAS Number: 127373-66-4

Purity: ≥95%

Molecular Weight: 434.46

Molecular Formula: C₂₀H₂₂N₂O₇S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Click on image or enlarge button to enlarge

Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC₅₀ = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreas elastase (IC₅₀ = 5.6 μM). Sivelestat does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM. Sivelestat effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability. Sivelestat is also reported to inhibit mast cell Stat6-protease.

References

1. Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. 2. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.

Physical State :

Solid

Solubility :

Soluble in DMSO.

Storage :

Store at 4° C

Melting Point :

218-220° C

Density :

1.37 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.60 (Predicted)

IC50 :

Neutrophil Elastase: IC₅₀ = 44 nM (human)

Ki Data :

Neutrophil Elastase: K_i= 200 nM (human)

pK Values :

pK_a: 3.67 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

107706

MDL Number :

MFCD00889071

SMILES :

CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Sivelestat (CAS 127373-66-4) Product Citations

See how others have used Sivelestat (CAS 127373-66-4). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 23155475 Gill, N. et al. 2012. PLoS ONE. 7: e49646.

Citations 1 to 2 of 2 total

I also want to know if this neutrophile elastase inhibitor could inhibit Pseudomonas elastase? I wonder if your campany have some information or products to specifically inhibit Pseudomonas elastase? Otherwise can you customize product?

Asked by: Jian L

Thank you for your question. In the context of this chemical, Sivelestat, there doesn’t seem to be any literature regarding inhibition of Pseudomonas elastase. Here is an article about Pseudomonas elastase that may be a helpful reference for your research, PMCID: PMC347797, In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives.

Answered by: Technical Support

Date published: 2017-08-03

Rated 5 out of 5 by JL from Masood et al Masood et al. (PubMed ID 26136527) used Sivelestat to inhibit neutrophil elastase activity to reduce lung macrophage influx into the lung after O2 exposure. -SCBT Publication Review

Date published: 2015-03-03

Choose a Store

Choose a Language

Choose a Currency