Sivelestat is a cell-permeable sulfanilide compound that acts as a potent, substrate-competitive, and highly specific inhibitor of neutrophil elastase (IC50 = 19-49 nM in rat, rabbit, hamster, human, and mouse leukocyte elastase). Sivelestat displays >100-fold greater selectivity over pancreas elastase (IC50 = 5.6 μM). Sivelestat does not inhibit trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G even at concentrations as high as 100 μM. Sivelestat effectively suppresses human neutrophil elastase-induced lung hemorrhage and skin capillary permeability. Sivelestat is also reported to inhibit mast cell Stat6-protease.
1. Suzuki, K., et al. 2003. Biochem. Biophys. Res. Commun. 309, 768. 2. Kawabata, K., et al. 1991. Biochem. Biophys. Res. Commun. 177, 814.
Soluble in DMSO.
Store at 4° C
1.37 g/cm3 (Predicted)
n20D 1.60 (Predicted)
Neutrophil Elastase: IC50 = 44 nM (human)
Neutrophil Elastase: Ki= 200 nM (human)
pKa: 3.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I also want to know if this neutrophile elastase inhibitor could inhibit Pseudomonas elastase? I wonder if your campany have some information or products to specifically inhibit Pseudomonas elastase? Otherwise can you customize product?
Asked by: Jian L
Thank you for your question. In the context of this chemical, Sivelestat, there doesn’t seem to be any literature regarding inhibition of Pseudomonas elastase. Here is an article about Pseudomonas elastase that may be a helpful reference for your research, PMCID: PMC347797, In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives.
Rated 5 out of
Masood et alMasood et al. (PubMed ID 26136527) used Sivelestat to inhibit neutrophil elastase activity to reduce lung macrophage influx into the lung after O2 exposure. -SCBT Publication Review
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