SIRT2 Inhibitor, AGK2 CAS: 304896-28-4
MF: C23H13Cl2N3O2
MW: 434.27
A reversible inhibitor of SIRT2 activity.

SIRT2 Inhibitor, AGK2 (CAS 304896-28-4)

SIRT2 Inhibitor, AGK2 | CAS 304896-28-4 is rated 5.0 out of 5 by 1.
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Alternate Names: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-5-quinolinylacrylamide
Application: SIRT2 Inhibitor, AGK2 is a reversible inhibitor of SIRT2 activity
CAS Number: 304896-28-4
Purity: ≥95%
Molecular Weight: 434.27
Molecular Formula: C23H13Cl2N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SIRT2 Inhibitor, AGK2 is a reversible inhibitor of sirtuin 2 (SIRT2), a histone deacetylase enzyme. Inhibition of SIRT2 has been correlated to protection against dopaminergic cell death in Parkinson′s disease models, and is also shown to rescue cells from toxicity conferred by alpha-synuclein expression. SIRT2 Inhibitor, AGK2 has little activity against SIRT1 and SIRT3 (IC50 >50 μM).


References

1. Auluck, Pavan K., et al., 2002. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson′s disease. Science (New York, N.Y.). 295(5556): 865-8. PMID: 11823645
2. Outeiro, Tiago Fleming., et al., 2007. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson′s disease. Science (New York, N.Y.). 317(5837): 516-9. PMID: 17588900

Physical State :
Solid
Solubility :
Soluble in DMSO (>5 mg/ml), DMF (3 mg/ml), and 1:2 DMF:PSB(pH 7.2) (0.3 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
283.64° C (Predicted)
Boiling Point :
675.09° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
sirtuin 2: IC50 = 3.5 µM; SIRT1/3: IC50 = >50 µM
pK Values :
pKa: 9.61 (Predicted), pKb: 4.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1183107
MDL Number :
MFCD01909444
SMILES :
C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N

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Certificate of Analysis

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SIRT2 Inhibitor, AGK2 (CAS 304896-28-4)  Product Citations

See how others have used SIRT2 Inhibitor, AGK2 (CAS 304896-28-4). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26022124  Binker, MG. et al. 2015. Biochemical and biophysical research communications. 463: 329-35.

PMID: # 20543840  Zhao, Y. et al. 2010. Nat. Cell Biol. 12: 665-675.

PMID: # 17588900  Outeiro, TF. et al. 2007. Science. 317: 516-519.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Outeiro et al Outeiro et al. (PubMed ID 17588900) used the SIRT2 inhibitor, AGK2, to disrupt cell cycle regulation by inactivating SIRT2 s ability to deacetylate alpha-tubulin. -SCBT Publication Review
Date published: 2015-05-02
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