SIRT1/2 Inhibitor IV, CambinolAn inhibitor of SIRT1, SIRT2, and SIRT5

SIRT1/2 Inhibitor IV, Cambinol (CAS 14513-15-6)

SIRT1/2 Inhibitor IV, Cambinol | CAS 14513-15-6 is rated 5.0 out of 5 by 1.
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Synonym: 5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
Application: An inhibitor of SIRT1, SIRT2, and SIRT5
CAS Number: 14513-15-6
Purity: >95%
Molecular Weight: 360.43
Molecular Formula: C21H16N2O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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SIRT1/2 Inhibitor IV, Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1 and SIRT2 (IC50 = 56 μM and 59 μM, respectively) in a substrate-, but not NAD-, competitive manner. SIRT1/2 Inhibitor IV, Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53.


References

Heltweg, B., et al. 2006. Cancer Res. 66, 4368

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml), and ethanol (5 mg/ml).
Storage :
Store at 4° C
Melting Point :
282.75° C (Predicted)
Boiling Point :
667° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
NAD-dependent deacetylase activity of hSIRT1: IC50 = 56 µM; NAD-dependent deacetylase activity of hSIRT2: IC50 = 59 µM; SIRT5 deacetylase activity: IC50 = >300 µM
pK Values :
pKa: 7.24 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3246390
MDL Number :
MFCD09057543
SMILES :
C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O

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Certificate of Analysis

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SIRT1/2 Inhibitor IV, Cambinol  Product Citations

See how others have used SIRT1/2 Inhibitor IV, Cambinol. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 25424328  Motonishi, S. et al. 2015. J. Am. Soc. Nephrol. 26: 1939-59.

PMID: # 19151729  Van Gool, F. et al. 2009. Nat. Med. 15: 206-210.

PMID: # 18344989  Prozorovski, T. et al. 2008. Nat. Cell Biol. 10: 385-394.

PMID: # 16618762  Heltweg, B. et al. 2006. Cancer Res. 66(8): 4368-4377.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Van Gool Van Gool, F. et al. (PubMed 19151729) used SIRT1/2 inhibitor IV, also known as cambinol, in murine dendritic cell lines causing a significant reduction in TNF- production. -SCBT Publication Review
Date published: 2015-05-14
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