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SIRT1/2 Inhibitor IV, Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1 and SIRT2 (IC50 = 56 μM and 59 μM, respectively) in a substrate-, but not NAD-, competitive manner. SIRT1/2 Inhibitor IV, Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53.
Heltweg, B., et al. 2006. Cancer Res. 66, 4368
See how others have used SIRT1/2 Inhibitor IV, Cambinol. Click on the entry to view the PubMed entry .
PMID: # 25424328 Motonishi, S. et al. 2015. J. Am. Soc. Nephrol. 26: 1939-59.
PMID: # 19151729 Van Gool, F. et al. 2009. Nat. Med. 15: 206-210.
PMID: # 18344989 Prozorovski, T. et al. 2008. Nat. Cell Biol. 10: 385-394.
PMID: # 16618762 Heltweg, B. et al. 2006. Cancer Res. 66(8): 4368-4377.
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