Sipholenol AAn inhibitor of P-glycoprotein(MDR-1) function

Sipholenol A (CAS 78518-73-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 65ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: (3R,5aR,6R,7S,9aR)-6-[2-[(1R,3aR,5S,8aR)-1-hydroxy-1,4,4, 6-tetramethyl-2,3,3a,5,8,8a-hexahydroazulen-5-yl]ethyl]-2,2,5a, 7-tetramethyl-4,5,6,8,9,9a-hexahydro-3H-benzo[b]oxepine-3,7-diol
Application: An inhibitor of P-glycoprotein(MDR-1) function
CAS Number: 78518-73-7
Molecular Weight: 476.73
Molecular Formula: C30H52O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Sipholenol A efficiently inhibits the function of P-glycoprotein (Pgp, MDR-1). It is a new reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. This has antiproliferative activity, and is cytotoxic. By inhibiting MDR-1, active compounds remain in the cytoplasm longer, allowing them to be more effective within the cell.


S. Carmely & Y. Kashman; J. Org. Chem. 48, 3517 (1983). S. Jain, et al.; J. Nat. Prod. 70, 928 (2007). Z. Shi, et al.; Cancer Sci. 98, 1373 (2007). S. Jain, et al.; Planta Med. 73, 591 (2007).

Appearance :
Physical State :
Derived From :
Solubility :
Soluble in DMSO or 100% ethanol (25mg/ml).
Storage :
Store at room temperature
Melting Point :
230.02° C (Predicted)
Boiling Point :
~572.3° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 2ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.