Siomycin AAn antibiotic that inhibits FoxM1

Siomycin A (CAS 12656-09-6)

Siomycin A | CAS 12656-09-6 is rated 5.0 out of 5 by 1.
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Synonym: Mutabilycin; Sporangiomycin
Application: An antibiotic that inhibits FoxM1
CAS Number: 12656-09-6
Purity: >95%
Molecular Weight: 1648.8
Molecular Formula: C71H81N19O18S5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Siomycin A, an antibiotic thiazole compound, has been shown to down-regulate the mRNA and protein abundance as well as transcriptional activity of transcription factor forkhead box M1 (FoxM1). Consequentially, it was demonstrated that the downstream target genes of FoxM1, such as CENP-B, Survivin, and Cdc25B were repressed. This compound was also reported to induce potent p53-independent apoptosis in cancer cell lines of different origin.


References

1. Radhakrishnan, S.K., et al. 2006. Cancer Res. 66: 9731-9735. PMID: 17018632
2. Liao, R., et al. 2009. Chem. Biol. 16: 141-147. PMID: 19246004
3. Bhat, U.G., et al. 2009. PLoS ONE. 4: e5592. PMID: 19440351
4. Pandit, B. and Gartel, A.L. 2010. Prostate. 70: 825-833. PMID: 20058240

Physical State :
Solid
Derived From :
Streptomyces sp. MST-AS4617
Solubility :
DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16130049
SMILES :
CC=C1C2=NC(CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC4C(OC(=O)C5=NC6=C(C=CC(C6O)NC(C(=O)NC(=C)C(=O)NC(=C)C(=O)NC(C(=O)NC7(CCC(=NC7C8=CSC4=N8)C9=NC(=CS9)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C2=NC(=CS2)C(=O)NC(C(=O)N1)C(C)O)C)C(C)C)C(=C5)C(C)O)C)C(C)(C(C)O)O

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Siomycin A  Product Citations

See how others have used Siomycin A. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 22945237  Kuner, R. et al. 2013. J. Mol. Med. 91: 237-48.

PMID: # 17018632  Radhakrishnan, SK. et al. 2006. Cancer Res. 66: 9731-9735.

PMID: # 4310238  Ebata, M. et al. 1969. J. Antibiot. 22: 364-368.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Radhakrishnan Radhakrishnan, SK. et al. (PubMed 17018632) tested Siomycin A, an antibiotic that inhibits FoxM1, in C3 cell line for its potential anticancer applications. They found that Siomycin A not only inhibited FoxM1 but suppressed the downstrem target genes of FoxM1 and induced apoptosis selectively in transformed but not normal cells of the same origin. -SCBT Publication Review
Date published: 2015-02-15
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