Siomycin A, an antibiotic thiazole compound, has been shown to down-regulate the mRNA and protein abundance as well as transcriptional activity of transcription factor forkhead box M1 (FoxM1). Consequentially, it was demonstrated that the downstream target genes of FoxM1, such as CENP-B, Survivin, and Cdc25B were repressed. This compound was also reported to induce potent p53-independent apoptosis in cancer cell lines of different origin.
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See how others have used Siomycin A. Click on the entry to view the PubMed entry .
PMID: # 22945237 Kuner, R. et al. 2013. J. Mol. Med. 91: 237-48.
PMID: # 17018632 Radhakrishnan, SK. et al. 2006. Cancer Res. 66: 9731-9735.
PMID: # 4310238 Ebata, M. et al. 1969. J. Antibiot. 22: 364-368.
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