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Sinefungin is a DNA methyltransferase (Dnmt) inhibitor and an analog of s-adenosyl-L-methionine (SAM) as indicated by previous studies. In studies investigating cytosine deamination by Dnmt, it was noted that the presence of sinefungin increased the rate of deamination 103 fold in the presence of its analog SAM, and 104 in the absence of SAM. This may suggest that sinefungin could be useful as a test compound in antiviral, anticancer, antiparasitic and antifungal applications. Additional studies indicate that sinefungin was able to inhibit RNA synthesis in a vaccinia virion preparation.
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See how others have used Sinefungin. Click on the entry to view the PubMed entry .
PMID: # 26202969 Liu, RJ. et al. 2015. Nucleic acids research. 43: 7489-503.
PMID: # 24128079 Fu, X. et al. 2014. Mol Ecol Resour. 14: 184-98.
PMID: # 25050323 Yadav, MK. et al. 2014. BioMed research international. 2014: 156987.
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