Simvastatin, Sodium SaltAn HMGCR inhibitor

Simvastatin, Sodium Salt (CAS 12009-77-6)

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Synonym: Simvastatin hydroxy acid sodium salt
Application: An HMGCR inhibitor
CAS Number: 12009-77-6
Molecular Weight: 458.57
Molecular Formula: C25H39O6•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Simvastatin, Sodium Salt is the carboxylate form of Simvastatin (sc-200829), a lipophilic HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase) inhibitor.


References

1. Keyomarsi, K., et al. 1991. Cancer Res. 51: 3602-3609. PMID: 1711413
2. Nègre-Aminou, P., et al. 1997. Biochim. Biophys. Acta. 1345: 259-268. PMID: 9150246
3. Vrtovsnik, F., et al. 1997. Kidney Int. 52: 1016-1027. PMID: 9328940
4. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102: 522-527. PMID: 9695968
5. Yada, T., et al. 1999. Br. J. Pharmacol. 126: 1205-1213. PMID: 10205010

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), ethanol (25 mg/ml), and DMF (~10 mg/ml).
Storage :
Store at -20° C
IC50 :
TNF-induced NF-κB activation: IC50 = 13 µM; chloroquine-sensitive Plasmodium falciparum IMT031: IC50 = 36.9 µM (Plasmodium falciparum); chloroquine-resistant Plasmodium falciparum Bre1: IC50 = 48.4 µM (Plasmodium falciparum); chloroquine-sensitive Plasmodium falciparum D6: IC50 = 51.3 µM (Plasmodium falciparum)
Ki Data :
HMG-CoA reductase: Ki= 0.12 nM
pK Values :
pKa: 4.31 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760655
MDL Number :
MFCD04974206
SMILES :
CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)C.[Na+]

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Certificate of Analysis

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Simvastatin, Sodium Salt  Product Citations

See how others have used Simvastatin, Sodium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 10205010  Yada, T. et al. 1999. Br. J. Pharmacol. 126: 1205-1213.

PMID: # 9695968  Clutterbuck, RD. et al. 1998. Br. J. Haematol. 102: 522-527.

PMID: # 9328940  Vrtovsnik, F. et al. 1997. Kidney Int. 52: 1016-1027.

PMID: # 9150246  Nègre-Aminou, P. et al. 1997. Biochim. Biophys. Acta. 1345: 259-268.

PMID: # 1711413  Keyomarsi, K. et al. 1991. Cancer Res. 51: 3602-3609.

Citations 1 to 5 of 5 total
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