Silybin CAS: 22888-70-6
MF: C25H22O10
MW: 482.44

Silybin (CAS 22888-70-6)

Silybin | CAS 22888-70-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Silibinin; 2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin; Silymarin
Application: Silybin is a major active constituent of silymarin which inhibits mitogen-activated protein kinase (MAPK)
CAS Number: 22888-70-6
Purity: >98%
Molecular Weight: 482.44
Molecular Formula: C25H22O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Silybin is an inhibitor of a wide variety of proteins, many of which are heavily involved in xenobiotic efflux and metabolism. Silybin is an inhibitor of P-glycoprotein-mediated cellular efflux and also inhibits xenobiotic oxidation by the CYP (cytochrome P450) superfamily of enzymes. This helps to contribute the apoptotic activity of this compound, which has been shown to be effective against a wide variety of cancer cell lines. Silybin is an inhibitor of 5-LO.


References

[On the chemistry of silymarin (silybin), the active principle of the fruits from Silybum marianum (L.) Gaertn. (Carduus marianus L.)]: H. Wagner, et al.; Arzneimittelforschung 18, 688 (1968) Inhibition of Kupffer cell functions as an explanation for the

Physical State :
Solid
Solubility :
Soluble in ethanol (<1 mg/ml at 25° C), DMSO (21 mg/ml at 25° C), DMF (~20 mg/ml), water (0.5 mg/ml at 25.0° C), and methanol.
Storage :
Store at -20° C
Melting Point :
167° C
Boiling Point :
793.03° C at 760 mmHg (Predicted)
Density :
1.53 g/cm3 at 20° C
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
HUVEC50: IC50 = 8.83 µM (human); Leukotriene B synthesis: IC50 = 15 µM; HIV-1(RF): IC50 = 66.5 µM (CEM); Block superoxide production: EC5050 = 100 µM (PMA-activated rat Kupffer cells)
pK Values :
pKa: 7.39 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD00872186
EC Number :
245-302-5
SMILES :
COC1=C(C=CC(=C1)[[email protected]@H]2[[email protected]](OC3=C(O2)C=C(C=C3)[[email protected]@H]4[[email protected]](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

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Certificate of Analysis

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Silybin (CAS 22888-70-6)  Product Citations

See how others have used Silybin (CAS 22888-70-6). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 24798868  Liang, Z. et al. 2014. Mol. Cancer Ther. 13: 1860-72.

PMID: # 17916909  Singh, RP. et al. 2007. Carcinogenesis. 28: 2567-2574.

PMID: # 14504208  Singh, RP. et al. 2003. Cancer Epidemiol. Biomarkers Prev. 12: 933-939.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Singh Singh, et. al. (PubMed ID 17916909) found that treating nude mice before and/or after of human prostate carcinoma PC-3 tumor xenograft implantation inhibited the tumor growth rate; showing a decrease in tumor volume and tumor weight (per mouse). -SCBT Publication Review
Date published: 2015-03-01
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