Ser/Thr Phosphorylation Induction CocktailA combination of chemicals that promotes and maintains the Ser/Thr phosphorylation state of a variety of proteins

Ser/Thr Phosphorylation Induction Cocktail

Ser/Thr Phosphorylation Induction Cocktail is rated 5.0 out of 5 by 1.
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Application: A combination of chemicals that promotes and maintains the Ser/Thr phosphorylation state of a variety of proteins
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Ser/Thr Phosphorylation Induction Cocktail is a synergistic combination of chemicals designed to promote and maintain the phosphorylation state of a wide variety of phosphorylated proteins.
Ser/Thr Phosphorylation Induction Cocktail is a tested and verified proprietary formula containing PMA, forskolin, calyculin A, and okadaic acid specifically designed for broad-spectrum protein phosphorylation research.
Ser/Thr Phosphorylation Induction Cocktail has been shown to activate PKC, PKA, and inhibit Ser/Thr phosphatases 1 and 2A.
Suitable for use in Western Blotting, Flow Cytometry, and ImmunoFluorescence applications.


References

1. Kovacs, C.S. et al. 1995. Mol. Cell. Endocrinol. 110(1-2): 9-16. PMID: 7545625
2. Leung, Y.M. et al. 1997. Eur. J. Pharmacol. 331(2-3): 337-340. PMID: 9274998
3. Andrews, D.A. et al. 2002. Blood. 100(9): 3392-3399. PMID: 12384442
4. Gates, J. et al. 2004. J. Pharmacol. Exp. Ther. 310(2): 536-545. PMID: 15064333
5. Davies, S.L. et al. 2007. J. Biol. Chem. 282(20): 15048-15056. PMID: 17376781
6. Su, T.R. et al. 2009. Acta Pharmacol. Sin. 30(9): 1220-1226. PMID: 19701239

Usage :
Provided in 2ml DMSO, sufficient to treat 200 ml of culture media. Recommended induction times of 30 minutes to 2 hours. Since applications and expression levels vary; the optimal working dilution should be determined by the researcher.
Formulation :
Every 2 ml contains: 10 µM Okadaic Acid (sc-3513); 2.5 µM Calyculin A (sc-24000); 20 µM PMA (sc-3576); 5 mM Forskolin (sc-3562)
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Rated 5 out of 5 by from This cocktail contains PMA This cocktail contains PMA, forskolin, calyculin A, and okadaic acid, along with other proprietary ingredients. This formula makes it useful for use in broad spectrum protein phosphorylation research. As a Serine/Threonine phosphorylation induction cocktail, it is suitable for use to activate PKC, PKA, while inhibiting Ser/Thr phosphatases 1 and 2A. SCBT recommends using this cocktail for WB, FCM, IF applications. -SCBT QC
Date published: 2015-02-25
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