SedanolideAn inducer of GST and inhibitor of Cox-1, Cox-2, Topo I, Topo II, and carcinogenesis

Sedanolide (CAS 6415-59-4)

Sedanolide | CAS 6415-59-4 is rated 5.0 out of 5 by 1.
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Synonym: 3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one
Application: An inducer of GST and inhibitor of Cox-1, Cox-2, Topo I, Topo II, and carcinogenesis
CAS Number: 6415-59-4
Purity: ≥98%
Molecular Weight: 194.27
Molecular Formula: C12H18O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sedanolide is an inducer of glutathione S-transferases (GSTs) and inhibitor of chemically induced carcinogenesis. It was shown to inhibit cyclooxygenase-1 and -2 (Cox-1 and -2) as well as topoisomerase I and topoisomerase II (Topo I and Topo II). Sedanolide is mosquitocidal, nematicidal and antifungal.


References

1. Zheng, G.Q., et al. 1993. Nutr. Cancer. 19: 77-86. PMID: 8446516
2. Momin, R.A., et al. 2001. J. Agric. Food Chem. 49: 142-145. PMID: 11305251
3. Woods, J.A., et al. 2001. In. Vitr. Mol. Toxicol. 14: 233-240. PMID: 11846995
4. Momin, R.A. and Nair, M.G. 2002. Phytomedicine. 9: 312-318. PMID: 12120812

Physical State :
Solid
Derived From :
Apium graveolens L.
Solubility :
Soluble in 100% ethanol , acetonitrile, methanol, and ethyl acetate.
Storage :
Store at -20° C
Melting Point :
47.53° C (Predicted)
Boiling Point :
~342.0° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3
Refractive Index :
n20D 1.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5018391
MDL Number :
MFCD00171327
SMILES :
CCCCC1C2CCCC=C2C(=O)O1

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Certificate of Analysis

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Is SC-205972 trans or cis?

Asked by: Jz28sail
Thank you for your question. For the compound, sc-205972, we do not characterize whether it is cis or trans. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-07
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Rated 5 out of 5 by from Momin et al (PubMed ID 11305251) found that Momin et al (PubMed ID 11305251) found that sedanolide was a prostaglandin H endoperoxide synthase- (COX-1) and Cox-II inhibitor at pH 7 and also inhibited topoisomerase I/II activity. -SCBT Publication Review
Date published: 2015-05-12
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