Sedanolide is an inducer of glutathione S-transferases (GSTs) and inhibitor of chemically induced carcinogenesis. It was shown to inhibit cyclooxygenase-1 and -2 (Cox-1 and -2) as well as topoisomerase I and topoisomerase II (Topo I and Topo II). Sedanolide is mosquitocidal, nematicidal and antifungal.
1. Zheng, G.Q., et al. 1993. Nutr. Cancer. 19: 77-86. PMID: 8446516 2. Momin, R.A., et al. 2001. J. Agric. Food Chem. 49: 142-145. PMID: 11305251 3. Woods, J.A., et al. 2001. In. Vitr. Mol. Toxicol. 14: 233-240. PMID: 11846995 4. Momin, R.A. and Nair, M.G. 2002. Phytomedicine. 9: 312-318. PMID: 12120812
Apium graveolens L.
Soluble in 100% ethanol , acetonitrile, methanol, and ethyl acetate.
Store at -20° C
47.53° C (Predicted)
~342.0° C at 760 mmHg (Predicted)
n20D 1.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Is SC-205972 trans or cis?
Asked by: Jz28sail
Thank you for your question. For the compound, sc-205972, we do not characterize whether it is cis or trans. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
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Momin et al (PubMed ID 11305251) found thatMomin et al (PubMed ID 11305251) found that sedanolide was a prostaglandin H endoperoxide synthase- (COX-1) and Cox-II inhibitor at pH 7 and also inhibited topoisomerase I/II activity. -SCBT Publication Review
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