SecurinineA GABA receptor antagonist

Securinine (CAS 5610-40-2)

Securinine | CAS 5610-40-2 is rated 5.0 out of 5 by 1.
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Synonym: Virosecurinine; (-)-Securinine
Application: A GABA receptor antagonist
CAS Number: 5610-40-2
Molecular Weight: 217.26
Molecular Formula: C13H15NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Securinine is extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity.


References

Friess, S.L., et al.: Toxicol. Appl. Pharmacol., 3, 347 (1961)

Physical State :
Solid
Solubility :
Soluble in alcohol, and DMSO (≥25 mg/ml).
Storage :
Store at -20° C
Melting Point :
140-1420° C (lit.)
Boiling Point :
458.96° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20/D -997.5°±17.5°, c = 1 in methanol
IC50 :
GABA receptor gamma-1 subunit: IC50 = 50 µM (rat); KB : IC50 = 2.2 µg/ml (human); L1210 : IC50 = 1.9 µg/ml (mouse); GABA receptor alpha-2 subunit: IC50 = 50 µM (rat)
pK Values :
pKb: 8.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
VS4115000
PubChem CID :
442872
Merck Index :
14: 8422
MDL Number :
MFCD00867422
SMILES :
C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4

Download SDS (MSDS)

Certificate of Analysis

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Securinine  Product Citations

See how others have used Securinine. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25697356  Zhao, G. et al. 2015. The Journal of biological chemistry. 290: 8949-63.

PMID: # 23904594  Obukuro, K. et al. 2013. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33: 12557-68.

Citations 1 to 2 of 2 total

Bonjour, connaissez vous le ratio des formes isomères (+) et (-)  dans vos batch de securinine ? Merci pour votre aide

Asked by: Phileal
Merci pour votre question. Ce produit est l'isomère (-). Ceci est déterminé en fonction de la rotation spécifique. Ce produit est un simple isomère optiquement pur. "What are the isomer ratios in this product?" Thank you for your question. This product is the (-) isomer. This is determined based on the specific rotation. This product is an optically pure single isomer.
Answered by: Tech Support Europe
Date published: 2019-08-05
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Rated 5 out of 5 by from Chen Chen, CR. et al. (PubMed 22570942) reported that Securinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. -SCBT Publication Review
Date published: 2015-03-18
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