SDZ 205-557 hydrochlorideA SR-3 and SR-4 antagonist

SDZ 205-557 hydrochloride (CAS 137196-67-9)

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Synonym: 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
Application: A SR-3 and SR-4 antagonist
CAS Number: 137196-67-9
Purity: >99%
Molecular Weight: 337.25
Molecular Formula: C14H21ClN2O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SDZ 205-557 hydrochloride acts as a SR-3 and SR-4 antagonist.


References

Buchheit et al (1992) SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn-Schmied.Arch.Pharmacol. 345 387. Eglen et al (1993) The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Br.J.Pharmacol. 108 376. McMahon and Cunningham (1999) Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J.Pharmacol.Exp.Ther. 291 300.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/mL), and water (65 mg/mL). Insoluble in ethanol.
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957705
MDL Number :
MFCD00671790
SMILES :
CCN(CC)CCOC(=O)C1=CC(=C(C=C1OC)N)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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