SCML1 Antibody (8-RY28): sc-135622

SCML1 Antibody (8-RY28) is a mouse monoclonal IgG2a kappa light chain antibody that detects SCML1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-SCML1 antibody (8-RY28) is available as the non-conjugated format. SCML1, or sex comb on midleg-like 1 (Drosophila), is a 329 amino acid protein that plays a crucial role in regulating gene expression through involvement in Polycomb group (PcG) protein complexes, which maintain the transcriptional repressive state of genes across cell generations. SCML1 is primarily localized in the nucleus, contributing to vital processes such as testis development, spermatogenesis, and embryonal development. SCML1 shows highest expression in adult skeletal muscle, heart, and fetal liver, indicating importance in these tissues. SCML1 gene spans 18 kb, consists of 6 exons, and is located on human chromosome Xp22.13, with transcription occurring from telomere to centromere. SCML1 features one sterile alpha motif (SAM) domain and exists in three isoforms due to alternative splicing events, which may have implications for functional diversity and regulatory mechanisms in various biological contexts.

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SCML1 Antibody (8-RY28) References:

1. Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22.  |  Montini, E., et al. 1999. Genomics. 58: 65-72. PMID: 10331946
2. Refinement of the NHS locus on chromosome Xp22.13 and analysis of five candidate genes.  |  Toutain, A., et al. 2002. Eur J Hum Genet. 10: 516-20. PMID: 12173028
3. Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.  |  Wu, HH. and Su, B. 2008. BMC Evol Biol. 8: 192. PMID: 18601738
4. Polycomb group complexes--many combinations, many functions.  |  Kerppola, TK. 2009. Trends Cell Biol. 19: 692-704. PMID: 19889541
5. Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes.  |  van de Vosse, E., et al. 1998. Genomics. 49: 96-102. PMID: 9570953

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCML1 Antibody (8-RY28) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SCML1 Antibody (8-RY28) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCML1 Antibody (8-RY28) Specifications

Alternate Product Name: SCML1

Product Clone Name: 8-RY28

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 3-101

Epitope Target: SCML1

Epitope Species: human

Product Reactivity/Detection: SCML1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SCML1 Antibody (8-RY28): N/A