SCH 23390 is a selective and highly effective dopamine D1DR (D1 ) and D5DR (D5) receptor antagonist. In vitro studies reveal that SCH 23390 has the ability to bind to the serotonin receptors 5-HT2 and SR-2C (5-HT1C). SCH 23390 has been used to research the topographical determination of D1 receptors in brain studies of multiple species, and the dopamine system.
1. Bourne, J.A. 2001. CNS Drug Rev. 7: 399-414. PMID: 11830757 2. Noda, Y., et al. 2010. Int. J. Neuropsychopharmacol. 13: 1343-1354. PMID: 20219155
Soluble in water (8 mg/mL), DMSO (3 mg/mL), and ethanol (2 mg/mL).
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Noda et alNoda et al. (PubMed ID 20219155) found that SCH 23390 prevented the ameliorating effect of galantamine on Meth-induced memory impairment in mice via dopamine D1 receptor inhibition. -SCBT Publication Review
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