SC68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase activity in a dose-dependent manner (IC50 = 2-5 μM). Does not inhibit basal ERK or IL-1-induced JNK activity.
1. p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta: Z. Guan, et al.; J. Biol. Chem. 272, 8083 (1997) 2. Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway: Z. Guan, et al.; J. Biol. Chem. 273, 12901 (1998) 3. Kooijiman, R., et al. Cell. Signal. 109, 1091-1098, (2003)
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