SC68376A reversible ATP-competitive, selective inhibitor of p38 MAP kinase

SC68376 (CAS 318480-82-9)

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Application: A reversible ATP-competitive, selective inhibitor of p38 MAP kinase
CAS Number: 318480-82-9
Purity: ≥98%
Molecular Weight: 236.3
Molecular Formula: C15H12N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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SC68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase activity in a dose-dependent manner (IC50 = 2-5 μM). Does not inhibit basal ERK or IL-1-induced JNK activity.


References

1. p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta: Z. Guan, et al.; J. Biol. Chem. 272, 8083 (1997) 2. Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway: Z. Guan, et al.; J. Biol. Chem. 273, 12901 (1998) 3. Kooijiman, R., et al. Cell. Signal. 109, 1091-1098, (2003)

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml).
Storage :
Store at 4° C
Melting Point :
141.52° C (Predicted)
Boiling Point :
352.30° C at 760 mmHg (Predicted)
Density :
1.15 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
MAP kinase p38: IC50 = 5 µM (human)
pK Values :
pKb: 3.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5174
MDL Number :
MFCD00940355
SMILES :
CC1=NC(=C(O1)C2=CC=NC=C2)C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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