SC514A selective and reversible inhibitor of IKKβ (IKK-2)

SC514 (CAS 354812-17-2)

SC514 | CAS 354812-17-2 is rated 5.0 out of 5 by 2.
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Synonym: IKK-2 Inhibitor
Application: A selective and reversible inhibitor of IKKβ (IKK-2)
CAS Number: 354812-17-2
Molecular Weight: 224.30
Molecular Formula: C9H8N2OS2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC50 = 20, 20, and 8 μM, respectively). Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.


References

1. Kishore, N., et al. 2003. J. Biol. Chem. 278: 32861-32871. PMID: 12813046
2. Baxter, A., et al. 2004. Bioorg. Med. Chem. Lett. 14: 2817-2822. PMID: 15125939
3. Gomez, A.B., et al. 2005. Br. J. Pharmacol 146: 217-225. PMID: 15997236 4. Phulwani, N.K., et al. 2008. J Immunol 181: 3841-3849. PMID: 18768838

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (45 mg/ml at 25° C), DMF (~25 mg/ml), aqueous buffers (sparingly), water (<1 mg/ml at 25° C), and ethanol (10 mM).
Storage :
Store at -20° C
Melting Point :
209-211° C
Boiling Point :
399.18° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
IKKβ: IC50 = 1.3 µM (human); NF-κB-mediated Cox-2 expression: IC50 = 8 µM (synovial fibroblasts stimulated with IL-1β); NF-κB-mediated IL-6 expression: IC50 = 20 µM (synovial fibroblasts stimulated with IL-1β); NF-κB-mediated IL-8 expression: IC50 = 20 µM (synovial fibroblasts stimulated with IL-1β)
pK Values :
pKb: 2.32 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2807869
MDL Number :
MFCD00206459
SMILES :
C1=CSC=C1C2=CC(=C(S2)C(=O)N)N

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SC514  Product Citations

See how others have used SC514. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 30484005  Shindo, S.|Hosokawa, Y.|Hosokawa, I.|Shiba, H.| et al. 2019. Inflammation. 42: 835-840.

PMID: # 30089134  Uddin, MM. et al. 2018. PLoS ONE. 13: e0201858.

PMID: # 28753407  Hosokawa, Y. et al. 2017. Immunol. Invest. 46: 615-624.

PMID: # 27536332  Osawa, M. et al. 2016. Infect. Agents Cancer. 11: 37.

PMID: # 26915562  Navarro, R. et al. 2016. Journal of cellular and molecular medicine. 20: 980-6.

PMID: # 22890916  Hu, LH. et al. 2012. Mol. Cell. Biochem. 371: 105-13.

PMID: # 22847000  Narayanan, A. et al. 2012. The Journal of biological chemistry. 287: 33198-214.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from SC514.caspase1 antibody This antibody is very easy to use in WB.I hope your company is getting better and better.
Date published: 2016-11-12
Rated 5 out of 5 by from Oenema Oenema, TA. et al. (PubMed 20875145) observed that pretreatment with GF109203X, a protein kinase C (PKC) inhibitor, completely normalized the effect of methacholine on cigarette smoke extract (CSE)-induced IL-8 secretion, whereas PMA, a PKC activator, mimicked the effects of methacholine, inducing IL-8 secretion and augmenting the effects of CSE. Similar inhibition was observed using inhibitors of I B-kinase-2 (SC514) and MEK1/2 (U0126), both downstream effectors of PKC. -SCBT Publication Review
Date published: 2015-07-10
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