SC-514 is a selective and reversible inhibitor of IKKβ (IKK-2) (IC50 = 3-12 μM) that displays >10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. This compound attenuates NF-κB-induced gene expression of IL-6, IL-8 and Cox-2 (IC50 = 20, 20, and 8 μM, respectively). Improper activation of NF-κB has been linked to cancer, immune and inflammatory diseases, and viral infection.
1. Kishore, N., et al. 2003. J. Biol. Chem. 278: 32861-32871. PMID: 12813046 2. Baxter, A., et al. 2004. Bioorg. Med. Chem. Lett. 14: 2817-2822. PMID: 15125939 3. Gomez, A.B., et al. 2005. Br. J. Pharmacol 146: 217-225. PMID: 15997236 4. Phulwani, N.K., et al. 2008. J Immunol 181: 3841-3849. PMID: 18768838
Soluble in DMSO (45 mg/ml at 25° C), DMF (~25 mg/ml), aqueous buffers (sparingly), water (<1 mg/ml at 25° C), and ethanol (10 mM).
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
SC514.caspase1 antibodyThis antibody is very easy to use in WB.I hope your company is getting better and better.
Date published: 2016-11-12
Rated 5 out of
OenemaOenema, TA. et al. (PubMed 20875145) observed that pretreatment with GF109203X, a protein kinase C (PKC) inhibitor, completely normalized the effect of methacholine on cigarette smoke extract (CSE)-induced IL-8 secretion, whereas PMA, a PKC activator, mimicked the effects of methacholine, inducing IL-8 secretion and augmenting the effects of CSE. Similar inhibition was observed using inhibitors of I B-kinase-2 (SC514) and MEK1/2 (U0126), both downstream effectors of PKC. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.