SC1 is a small molecule shown to sustain self-renewal of mouse embryonic stem (mES) cells. In order to maintain embryonic stem cells in an undifferentiated state, it is typically necessary to use a combination of feeder cells, leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP); SC1 (Pluripotin) allows for stem cell propagation in the absence of these factors. The activity of SC1 is mediated by Ras signaling which promotes self-renewal, and inhibition of ERK blocks differentiation.
1. Chen, S., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 17266-17271. PMID: 17088537 2. Xiong, W., et al. 2009. J Vis Exp. 18: PMID: 19924098
Soluble in water (0.3 mg/ml at 25° C), DMSO: PBS(1: 2) pH 7.2 (~0.3 mg/ml), DMF (~50 mg/ml), and DMSO (~25 mg/ml).
Store at -20° C
~1.4 g/cm3 (Predicted)
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
DuDu, et al. (PubMed ID 24556957) used SC1, an inhibitor of ERK-1 and RasGAP-dependent signaling pathways, to study cell morphological changes in embryonic carcinoma cells post treatment. -SCBT Publication Review
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