SC 58125 is a selective, time-dependent, and irreversible cyclooxygenase-2 (Cox-2) inhibitor that displays anti-inflammatory properties. In addition to inhibiting Cox-2 (IC50 of 0.04 μM), SC 58125 is found to reversibly inhibit Cox-1 (IC50 of >100 μM), which is expressed in most tissues and organs. Experiments suggest that SC 58125 is also capable of suppressing cell proliferation by causing a progression delay at the G2/M transition.
1. Seibert, K., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 12013-12017. PMID: 7991575 2. Gierse, J.K., et al. 1996. J. Biol. Chem. 271: 15810-15814. PMID: 8663121 3. Williams, C.S., et al. 2001. Neoplasia. 3: 428-436. PMID: 11687954
SC 58125 is supplied as a crystalline solid. A stock solution may be made by dissolving in an organic solvent purged with an inert gas. SC 58125 is soluble in organic solvents such as ethanol (10 mg/ml), DMSO (10 mg/ml), and dimethyl formamide (DMF, 30 mg/ml).
SC 58125 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, SC 58125 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. SC 58125 has a solubility of approximately 250 μg/ml in a 1:3 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Soluble to 100 mM in DMSO and to 25 mM in Ethanol
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Is this molecule cell permeable ?
Asked by: Sathya
Thank you for your question. It is not clear from the literature whether this compound, catalog number, sc-58125 is cell permeable or not. We do not perform any experiments with this compound to provide suggestions.
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