SB939A non-selective inhibitor of HDAC

SB939 (CAS 929016-96-6)

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Synonym: Pracinostat
Application: A non-selective inhibitor of HDAC
CAS Number: 929016-96-6
Molecular Weight: 358.48
Molecular Formula: C20H30N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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SB939 is a potent inhibitor of HDAC class I and II isoenzymes, HDAC1, HDAC2, HDAC3 HDAC4, HDAC5, HDAC7, HDAC8, HDAC9 and HDAC10 with the IC50 values ranging from 43 nM to 140 nM. HDAC6 shows an IC50 of 1008 nM. It markedly inhibits HDAC11 of the HDAC class IV enzymes with an IC50 of 93 nM. SB939 shows significant anti-proliferative activity against a wide variety of tumor cell lines, especially Leukemia cells and cutaneous T-cell Lymphoma cells with IC50 values ranging from 50 nM (H9 cells) to 170 nM (HEL92.1.7 cells).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
49855250
SMILES :
CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO

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Certificate of Analysis

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