SB 399885 hydrochlorideA SR-6 antagonist

SB 399885 hydrochloride (CAS 402713-80-8)

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Synonym: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamidehydrochloride
Application: A SR-6 antagonist
CAS Number: 402713-80-8
Molecular Weight: 482.81
Molecular Formula: C18H21Cl2N3O4S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SB 399885 hydrochloride is a potent, brain penetrant, and orally active SR-6 antagonist. It displays > 200-fold selectivity for SR-6 over other serotonin receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human SR-6 receptors, respectively).


References

Hirst et al (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109. Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models fo anxiety and depression. Neuropharmacology 52 1274. Foley et al (2008) The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Boiling Point :
620° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Ki Data :
SR-6: Ki= 0.78 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DB1680000
PubChem CID :
10277652
MDL Number :
MFCD09970355
SMILES :
COC1=C(C=C(C=C1)S(=O)(=O)NC2=CC(=CC(=C2OC)Cl)Cl)N3CCNCC3.Cl

Download SDS (MSDS)

Certificate of Analysis

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SB 399885 hydrochloride  Product Citations

See how others have used SB 399885 hydrochloride. Click on the entry to view the PubMed entry .

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PMID: # 29491159  Riva, L.|Song, OR.|Prentoe, J.|Helle, F.|L'homme, L.|Gattolliat, CH.|Vandeputte, A.|Fénéant, L.|Belouzard, S.|Baumert, TF.|Asselah, T.|Bukh, J.|Brodin, P.|Cocquerel, L.|Rouillé, Y.|Dubuisson, J.| et al. 2018. J. Virol. 92:

Citations 1 to 1 of 1 total
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