SB 269970 hydrochloride (CAS 201038-74-6)
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SB 269970 hydrochloride is a compound extensively studied in neuroscientific research due to its action as a selective antagonist of the 5-HT7 receptor. This specificity makes it useful in elucidating the role of this receptor subtype in neurological processes and behavior. Researchers employ SB 269970 hydrochloride in various experimental models to investigate its effects on circadian rhythm, mood regulation, and cognitive functions, which are believed to be influenced by serotonergic signaling. The compound is also used to understand the binding characteristics and signal transduction pathways associated with the 5-HT7 receptor. Furthermore, SB 269970 hydrochloride is a subject of interest in the exploration of the molecular mechanisms underlying psychiatric disorders. Its use in research helps to shed light on the complex interplay of neurotransmitter systems in the brain and contributes to the broader understanding of neuronal communication.
SB 269970 hydrochloride (CAS 201038-74-6) References
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- Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. | Hagan, JJ., et al. 2000. Br J Pharmacol. 130: 539-48. PMID: 10821781
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- Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors. | Honda, M., et al. 2003. Eur J Pharmacol. 482: 155-61. PMID: 14660017
- Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cord. | Madden, CJ. and Morrison, SF. 2008. Neuropharmacology. 54: 487-96. PMID: 18082230
- Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. | Galici, R., et al. 2008. Behav Pharmacol. 19: 153-9. PMID: 18332680
- Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. | Fox, MA., et al. 2008. Psychopharmacology (Berl). 201: 203-18. PMID: 18712364
- Serotonergic modulation of extrapyramidal motor disorders in mice and rats: role of striatal 5-HT3 and 5-HT6 receptors. | Ohno, Y., et al. 2011. Neuropharmacology. 60: 201-8. PMID: 20813116
- On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor. | Naumenko, VS., et al. 2011. Neuropharmacology. 61: 1360-5. PMID: 21884711
- Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. | Nikiforuk, A., et al. 2013. PLoS One. 8: e66695. PMID: 23776692
- Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial hepatectomy. | Tzirogiannis, KN., et al. 2014. BMC Gastroenterol. 14: 201. PMID: 25433672
- Serotonin induces peripheral mechanical antihyperalgesic effects in mice. | Diniz, DA., et al. 2015. Eur J Pharmacol. 767: 94-7. PMID: 26460149
- Activation of the 5-HT7 receptor but not nitric oxide synthase is necessary for chronic 5-hydroxytryptamine-induced hypotension. | Seitz, BM., et al. 2020. Exp Physiol. 105: 2025-2032. PMID: 33052620
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SB 269970 hydrochloride, 10 mg | sc-361342 | 10 mg | $295.00 | |||
SB 269970 hydrochloride, 50 mg | sc-361342A | 50 mg | $1020.00 |