SB 239063 is a potent and selective p38 MAP kinase inhibitor. This chemical displays greater than 220-fold selectivity over ERK, JNK1 and other kinases, is approximately 3-fold more selective than SB 203580, and is selective for p38 α and p38 β with no activity against γ and δ isoforms. SB 239063 has been shown to decrease the number of activated microglia and facilitates neurogenesis. It also reduces inflammatory cytokine production and is neuroprotective.
1. Stinson, L.F. et al. 2014. Reproduction. 147(3): 313-320. PMID: 24493151
Soluble in 11 mg/ml DMSO
Store at -20° C
~594.76° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Stinson et alStinson et al. (PubMed ID 24493151) found that SB239063 prevented accumulation of cytokines and PGE2 in the fetal and maternal compartment and also suppressed oIL8 production in pregnant patients who received intra-amniotically delivered CSAIDs for the prevention of inflammation-mediated preterm births.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.