SB 225002A selective antagonist of CXCR2

SB 225002 (CAS 182498-32-4)

SB 225002 | CAS 182498-32-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_18, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202803, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 69ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea; 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Application: A selective antagonist of CXCR2
CAS Number: 182498-32-4
Purity: >98%
Molecular Weight: 352.14
Molecular Formula: C13H10BrN3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.


References

1. White, J.R., et al. 1998. J. Biol. Chem. 273: 10095-10098. PMID: 9553055
2. Bento, A.F., et al. 2008. J. Leukoc. Biol. 84: 1213-1221. PMID: 18653784

Usage :
A stock solution in an organic solvent may be made by dissolving SB 225002 in the solvent and then purging it with inert gas. A stock solution in an aqueous solvent for use in biological experiments may be made by diluting the organic solvent into aqueous buffers or isotonic salts. Aqueous stock solutions should not be stored for longer than a day.
Physical State :
Solid
Solubility :
Soluble in DMSO (40 mg/ml), DMF (~30 mg/ml), methanol (15 mg/ml), acetonitrile (2 mg/ml, slightly), and ethanol (75 mM).
Storage :
Store at -20° C
Melting Point :
212.46° C (Predicted)
Boiling Point :
401.56° C at 760 mmHg (Predicted)
Density :
1.79 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
IL-8-mediated calcium mobilisation: IC50 = 8 nM; GROα-mediated calcium mobilisation: IC50 = 10 nM; neutrophil chemotaxis in response to IL-8: IC50 = 20 nM; CXCR2 chemokine receptor: IC50 = 22 nM; neutrophil margination induced by IL-8: IC50 = 30 nM
pK Values :
pKa: 5.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3854666
MDL Number :
MFCD00954637
SMILES :
C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 60ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Cao Cao, DL. et al. (PubMed 24852102) used the CXCR2 antagonist, SB 225002, to demonstrate that chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. -SCBT Publication Review
Date published: 2015-02-18
  • y_2019, m_11, d_18, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202803, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 37ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.