SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels. Further studies suggest that SB 225002 decreases the expression of vascular endothelial growth factor, inducible NOS (NO synthase), and Cox-2 (cyclooxygenase-2 proteins) in colon tissue.
1. White, J.R., et al. 1998. J. Biol. Chem. 273: 10095-10098. PMID: 9553055 2. Bento, A.F., et al. 2008. J. Leukoc. Biol. 84: 1213-1221. PMID: 18653784
A stock solution in an organic solvent may be made by dissolving SB 225002 in the solvent and then purging it with inert gas. A stock solution in an aqueous solvent for use in biological experiments may be made by diluting the organic solvent into aqueous buffers or isotonic salts. Aqueous stock solutions should not be stored for longer than a day.
Soluble in DMSO (40 mg/ml), DMF (~30 mg/ml), methanol (15 mg/ml), acetonitrile (2 mg/ml, slightly), and ethanol (75 mM).
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CaoCao, DL. et al. (PubMed 24852102) used the CXCR2 antagonist, SB 225002, to demonstrate that chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. -SCBT Publication Review
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