SB 205384 is a GABAA receptor modulator; slows current decay. Displays some specificity for α3-subunit-containing receptors (in particular α3β2γ2). Has little effect on receptors containing α1 or α2 subunits.
Meadows et al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334. Meadows et al (1998) SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253. Hutcheon et al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522.1 3.