SB 205384 CAS: 160296-13-9
MF: C17H18N2O3S
MW: 330.40
A GABAA receptor modulator.

SB 205384 (CAS 160296-13-9)

SB 205384 | CAS 160296-13-9 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester
Application: SB 205384 is a GABAA receptor modulator
CAS Number: 160296-13-9
Molecular Weight: 330.40
Molecular Formula: C17H18N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SB 205384 is a GABAA receptor modulator; slows current decay. Displays some specificity for α3-subunit-containing receptors (in particular α3β2γ2). Has little effect on receptors containing α1 or α2 subunits.


References

Meadows et al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334. Meadows et al (1998) SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253. Hutcheon et al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522.1 3.

Physical State :
Solid
Solubility :
Soluble to 50 mM in DMSO and to 100 mM in 1eq. HCl
Storage :
Desiccate at room temperature
Melting Point :
218-220° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC#CCOC(=O)C1=C(N=C2C(=C1N)C3=C(S2)CC(CC3)O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Heidelberg el al Heidelberg el al. (PubMed ID 23902941) found that SB-205384 was not a 3-selective modulator but was a positive allosteric modulator of recombinant GABAA receptor isoforms. -SCBT Publication Review
Date published: 2015-04-12
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