SauchinoneA diastereomeric lignan with cytoprotective and anitoxidant activites

Sauchinone (CAS 177931-17-8)

Sauchinone | CAS 177931-17-8 is rated 5.0 out of 5 by 2.
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Application: A diastereomeric lignan with cytoprotective and anitoxidant activites
CAS Number: 177931-17-8
Molecular Weight: 356.4
Molecular Formula: C20H20O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sauchinone is a diastereomeric ligand with cytoprotective and antioxidant activities in cultured hepatocytes. Sauchinone is an inhibitor of LPS-inducible iNOS (NOS II), TNF-α and Cox-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Sauchinone also acts as a suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit and inhibits staurosporine-induced apoptosis. Sauchinone inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.


References

S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000). S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000). A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003). H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003). B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003). K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) .

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, and chloroform.
Storage :
Store at room temperature
Melting Point :
186.28° C (Predicted)
Boiling Point :
498.10° C at 760 mmHg (Predicted)
Density :
1.44 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11725801
MDL Number :
MFCD08702698
SMILES :
C[C@@H]1C[C@@H]2[C@H]3[C@@H]([C@H]1C)C4=CC5=C(C=C4O[C@@]36C(=CC2=O)OCO6)OCO5

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Certificate of Analysis

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Rated 5 out of 5 by from Awesome Goods I have been using this products for several months. The purity and quality of the Sauchinone are pretty good so that I get a satisfactory experimental phenomena.
Date published: 2016-11-28
Rated 5 out of 5 by from Lee et al Lee et al. (PubMed ID 25451574) found that Sauchinone reduced CCl4-induced liver fibrosis and TGF- 1-induced hepatic stellate cell activation by reducing oxidative stress and autophagy. -SCBT Publication Review
Date published: 2015-05-03
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