Sauchinone is a diastereomeric ligand with cytoprotective and antioxidant activities in cultured hepatocytes. Sauchinone is an inhibitor of LPS-inducible iNOS (NOS II), TNF-α and Cox-2 expression in macrophages through suppression of IκBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may have constitutive anti-inflammatory effects. Sauchinone also acts as a suppressor of NF-κB by inhibiting transactivation activity of the RelA subunit and inhibits staurosporine-induced apoptosis. Sauchinone inhibits RANKL-induced osteoclastogenesis by reducing ROS generation.
S.H. Sung, et al.; Biol. Pharm. Bull. 23, 666 (2000). S.H. Sung & Y.C. Kim; J. Nat. Prod. 63, 1019 (2000). A.K. Lee, et al.; Br. J. Pharmacol. 139, 11 (2003). H. Song, et al.; Biol. Pharm. Bull. 26, 1428 (2003). B.Y. Hwang, et al.; Planta Med. 69, 1096 (2003). K.Y. Han, et al.; Biochem. Pharmacol. 74, 911 (2007) .
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.