Molecular structure of Sarafloxacin hydrochloride, CAS Number: 91296-87-6
Sarafloxacin hydrochloride (CAS 91296-87-6)
Alternate Names:
6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride
Application:
Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent
CAS Number:
91296-87-6
Purity:
≥98%
Molecular Weight:
421.82
Molecular Formula:
C20H17F2N3O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sarafloxacin hydrochloride is a fluoroquinolone antibiotic that functions by inhibiting the bacterial DNA gyrase enzyme, thereby preventing the supercoiling of DNA and ultimately disrupting the replication and transcription processes in susceptible bacteria. This disruption leads to the accumulation of double-stranded breaks in the bacterial DNA, resulting in cell death. This mechanism of action effectively hinders the growth and proliferation of susceptible bacterial pathogens.
Sarafloxacin hydrochloride (CAS 91296-87-6) References
- Metabolism of the veterinary fluoroquinolone sarafloxacin by the fungus Mucor ramannianus. | Parshikov, IA., et al. 2001. J Ind Microbiol Biotechnol. 26: 140-4. PMID: 11420653
- Pharmacokinetics of sarafloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications. | Ding, HZ., et al. 2001. J Vet Pharmacol Ther. 24: 303-8. PMID: 11696079
- Determination of difloxacin and sarafloxacin in chicken muscle using solid-phase extraction and capillary electrophoresis. | Barrón, D., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 767: 313-9. PMID: 11885860
- Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. | Fernandez-Teruel, C., et al. 2005. J Drug Target. 13: 199-212. PMID: 16036308
- In vitro residual anti-bacterial activity of difloxacin, sarafloxacin and their photoproducts after photolysis in water. | Kusari, S., et al. 2009. Environ Pollut. 157: 2722-30. PMID: 19473738
- Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference. | Rodríguez Cáceres, MI., et al. 2009. J Agric Food Chem. 57: 7627-33. PMID: 19689131
- Photolysis of difloxacin and sarafloxacin in aqueous systems. | Prabhakaran, D., et al. 2009. Chemosphere. 77: 739-46. PMID: 19751946
- Liquid chromatography combined with tandem mass spectrometry for the confirmation of sarafloxacin in catfish tissue. | Schilling, JB., et al. 1996. Anal Chem. 68: 1905-9. PMID: 21619101
- Determination of temafloxacin, sarafloxacin, and difloxacin in bulk drug and dosage forms by high-performance liquid chromatography. | Bauer, JF., et al. 1990. Pharm Res. 7: 1177-80. PMID: 2293219
- Production of the broad specific monoclonal antibody against sarafloxacin for rapid immunoscreening of 12 fluoroquinolones in meat. | Liu, YZ., et al. 2013. J Environ Sci Health B. 48: 139-46. PMID: 23305282
- A rapid and reliable assay to determine flumequine, marbofloxacin, difloxacin, and sarafloxacin in commonly consumed meat by micellar liquid chromatography. | Peris-Vicente, J., et al. 2019. J Sci Food Agric. 99: 1375-1383. PMID: 30120781
- Preparation of monodisperse, restricted-access, media-molecularly imprinted polymers using bi-functional monomers for solid-phase extraction of sarafloxacin from complex samples. | Cai, T., et al. 2021. J Chromatogr A. 1642: 462009. PMID: 33721811
- Self-constrained DNAzyme for aptamer-based and sensitive label-free fluorescent assay of sarafloxacin via signal amplification cascades. | Wang, Q., et al. 2023. Analyst.. PMID: 37158381
- Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C. | Martinsen, B. and Horsberg, TE. 1995. Antimicrob Agents Chemother. 39: 1059-64. PMID: 7625789
Inhibitor of:
Topo II alpha.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sarafloxacin hydrochloride, 5 g | sc-203255 | 5 g | $82.00 | |||
Sarafloxacin hydrochloride, 25 g | sc-203255A | 25 g | $131.00 |