SANT-2CAS: 329196-48-7
MF: C26H26ClN3O4
MW: 480.0
An inhibitor of Smo (Hedgehog signaling pathway) and SAG.

SANT-2 (CAS 329196-48-7)

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Synonym: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Application: An inhibitor of Smo (Hedgehog signaling pathway) and SAG
CAS Number: 329196-48-7
Molecular Weight: 480.0
Molecular Formula: C26H26ClN3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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SANT-2 is a cell permeable antagonist of the Smo protein function and an inhibitor of SAG activity. SANT-2 has been used as al tool to study the Hedgehog (Hh) signaling pathway and to explore therapeutic uses for inhibitors of Smo. Because hedgehog over activation of has been observed among some cancers, SANT-2 and other Smo antagonists are being studied for their antitumor activities.


References

1. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 14071-14076. PMID: 12391318
2. Feldmann, G., et al. 2008. Gut. 57: 1420-1430. PMID: 18515410
3. Büttner, A., et al. 2009. Bioorg. Med. Chem. 17: 4943-4954. PMID: 19541490
4. Miller-Moslin, K., et al. 2009. J. Med. Chem. 52: 3954-3968. PMID: 19469545

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1367095
SMILES :
CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3

Download SDS (MSDS)

Certificate of Analysis

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