SANT-1A Smo inhibitor and Sonic Hedgehog signaling pathway antagonist

SANT-1 (CAS 304909-07-7)

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Synonym: (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
Application: A Smo inhibitor and Sonic Hedgehog signaling pathway antagonist
CAS Number: 304909-07-7
Purity: >95%
Molecular Weight: 373.49
Molecular Formula: C23H27N5
* Refer to Certificate of Analysis for lot specific data (including water content).
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SANT-1 is a membrane permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway by direct binding to Smo. This inhibition of Smo occurs equipotently by SANT-1 binding to both the oncogenic Smo and wild-type. When combined HDAC inhibitor SAHA, SANT-1 was able to suppress cellular proliferation and colony formation of Gemcitabine-resistant pancreatic adenocarcinoma cell lines Panc-1 and BxPC-3.


References

1. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1: 10. PMID: 12437772
2. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 14071-14076. PMID: 12391318
3. Chun, S.G., et al. 2009. Cancer Biol. Ther. 8: 1328-1339. PMID: 19421011
4. Wilson, C.W., et al. 2009. PLoS ONE. 4: e5182. PMID: 19365551

Physical State :
Solid
Solubility :
Soluble in DMSO (50 mM), water (<2 mg/ml), chloroform, methanol, and ethanol (25 mM).
Storage :
Store at -20° C
Melting Point :
109-111° C
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Smo: IC50 = 4.74 nM (human); Sonic hedgehog protein: IC50 = 20 nM (mouse)
pK Values :
pKb: 6.16 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6878030
MDL Number :
MFCD01827306
SMILES :
CC1=C(C(=NN1C2=CC=CC=C2)C)/C=N/N3CCN(CC3)CC4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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