Salvigenin (CAS 19103-54-9)

Salvigenin, a naturally occurring flavonoid abundant in various plants, including Salvia miltiorrhiza. As a highly oxygenated coumarin derivative, salvigenin has been extensively researched. Its proven anti-inflammatory, antioxidant, and anti-cancer activities in vitro make it an intriguing subject of study. Moreover, salvigenin has been reported to possess neuroprotective, hepatoprotective, and cardioprotective properties. While the exact mechanism of salvigenin′s action remains incompletely elucidated, it is believed to operate through multiple pathways. These include the inhibition of proinflammatory mediators, the induction of apoptosis, and the suppression of cell proliferation. Additionally, salvigenin has shown the capability to hinder the expression of nuclear factor-κB, a transcription factor in inflammation regulation, while also modulating the activity of various kinases and phosphatases. In vitro investigations have further bolstered the therapeutic potential of salvigenin. Notably, in human umbilical vein endothelial cells, salvigenin effectively inhibits the expression of vascular cell adhesion molecule-1, a vital mediator of inflammation. Similarly, in human leukemia cells, salvigenin has demonstrated its ability to induce apoptosis and impede cell proliferation. These findings underscore the potential of salvigenin as a neuroprotective agent and its impact on cellular oxidative stress. Given the multifaceted properties and compelling research findings associated with salvigenin, further exploration is warranted to fully unlock its potential benefits.