Salmeterol-d3 CAS: 497063-94-2
MF: C25H34D3NO4
MW: 418.58
A deuterated structural analog of albuterol.

Salmeterol-d3 (CAS 497063-94-2)

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Alternate Names: 4-Hydroxy-α1[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol-d3; GR-33343X-d3
Application: Salmeterol-d3 is a deuterated structural analog of albuterol
CAS Number: 497063-94-2
Molecular Weight: 418.58
Molecular Formula: C25H34D3NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Salmeterol-d3 is a deuterated β2-Adrenergic receptor (β2-AR) agonist and structural analog of albuterol.


References

1. Johnson, M., et al., 1990. The pharmacology of salmeterol. Lung. 168 Suppl(): 115-9. PMID: 1974668
2. Ullman, A., et al., 1990. Inhaled salmeterol and salbutamol in asthmatic patients. An evaluation of asthma symptoms and the possible development of tachyphylaxis. The American review of respiratory disease. 142(3): 571-5. PMID: 1975162
3. Twentyman, O P., et al., 1990. Protection against allergen-induced asthma by salmeterol. Lancet. 336(8727): 1338-42. PMID: 1978163

Physical State :
Solid
Solubility :
Soluble in water (<0.1%), methanol, and chloroform.
Storage :
Store at room temperature
Melting Point :
75-77° C
Boiling Point :
~603.0° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
β2-AR: IC50 = 5.01 nM (human)(unlabeled); β1-AR: IC50 = 501.19 nM (human) (unlabeled)
Ki Data :
β2-AR: Ki= 0.39 nM (human)(unlabeled); β1-AR: Ki= 801 nM (human)(unlabeled); β3-AR: Ki= 7.18 µM (human) (unlabeled)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD06658792
SMILES :
[2H]C([2H])(C1=C(C=CC(=C1)C([2H])(CNCCCCCCOCCCCC2=CC=CC=C2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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