SalermideAn inhibitor of SIRT1, SIRT2, and HDAC

Salermide (CAS 1105698-15-4)

Salermide | CAS 1105698-15-4 is rated 5.0 out of 5 by 1.
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Synonym: N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide
Application: An inhibitor of SIRT1, SIRT2, and HDAC
CAS Number: 1105698-15-4
Purity: ≥98%
Molecular Weight: 394.47
Molecular Formula: C26H22N2O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs).


References

1. Lara, E., et al. 2009. Oncogene. 28: 781-791. PMID: 19060927
2. Peck, B., et al. 2010. Mol. Cancer Ther. 9: 844-855. PMID: 20371709

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), DMF (~30 mg/ml), and DMSO : PBS (pH 7.2)(1:2) (~0.25 mg/ml).
Storage :
Store at -20° C
Boiling Point :
~666.67° C at 760 mmHg (Predicted)
Density :
~1.16 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Causes 90% apoptosis within 72 hours : IC50 = ~20 µM (MOLT4 leukemia cells); SIRT2: IC50 = 25 µM (human); SIRT1: IC50 = 40.3 µM (human)
pK Values :
pKa: 8.3 (Predicted), pKb: 3.13 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD12912446
SMILES :
CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43

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Certificate of Analysis

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Salermide  Product Citations

See how others have used Salermide. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24069483  Lancelot, J. et al. 2013. PLoS Negl Trop Dis. 7: e2428.

PMID: # 22932127  Contrepois, K. et al. 2012. Epigenetics & chromatin. 5: 15.

Citations 1 to 2 of 2 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Salermide is supplied as a crystalline solid. A stock solution may be made by dissolving the salermide in an organic solvent purged with an inert gas. Salermide is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of salermide in these solvents is approximately 30 mg/ml.
Answered by: Technical Support
Date published: 2017-01-24
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Rated 5 out of 5 by from Peck et al Peck et al. (PubMed ID 20371709) found that the SIRT inhibitor, Salermide, induced cell death in breast carcinoma cell lines and p53-deficient mouse fibroblasts. -SCBT Publication Review
Date published: 2015-03-23
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