SAGCAS: 912545-86-9
MF: C28H28ClN3OS
MW: 490.06
A potent agonist of Hedgehog (Hh) signalling.

SAG (CAS 912545-86-9)

SAG | CAS 912545-86-9 is rated 5.0 out of 5 by 1.
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Application: A potent agonist of Hedgehog (Hh) signalling
CAS Number: 912545-86-9
Purity: ≥95%
Molecular Weight: 490.06
Molecular Formula: C28H28ClN3OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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SAG is a potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function.


References

1. DeCamp, D.L. et al. 2000. J. Biol. Chem. 275(34): 26322-26327. PMID: 10835429

2. Ahn, S. and Joyner, A.L. 2005. Nature. 437(7060): 894-897. PMID: 16208373

3. Huangfu, D. and Anderson, K.V. 2006. Development. 133(1): 3-14. PMID: 16339192

4. Loulier, K. et al. 2006. J. Neurochem. 98(2): 530-542. PMID: 16805844

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/mL), and sparingly soluble in water (acidification with HCl increases water solubility).
Storage :
Store at -20° C
Melting Point :
45-50° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5284330
SMILES :
CNC1CCC(CC1)N(CC2=CC=CC(=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl

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Certificate of Analysis

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SAG  Product Citations

See how others have used SAG. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 28535764  Henno, P.|Grassin-Delyle, S.|Belle, E.|Brollo, M.|Naline, E.|Sage, E.|Devillier, P.|Israël-Biet, D.| et al. 2017. Respir. Res. 18: 102.

PMID: # 26286140  Lee, SJ. et al. 2015. Molecular cancer. 14: 159.

PMID: # 25913744  Messina, A. et al. 2015. Stem Cells. 33: 2496-508.

PMID: # 25044881  Bertacchi, M. et al. 2015. Dev Neurobiol. 75: 66-79.

PMID: # 25892363  O'Brien, LC. et al. 2015. Stem Cells Dev. 24: 1984-94.

PMID: # 26370082  Fu, X. et al. 2015. J. Biol. Chem. 290: 26445-56.

PMID: # 25260753  Melboucy-Belkhir, S. et al. 2014. American journal of physiology. Lung cellular and molecular physiology. 307: L838-47.

PMID: # 25492966  Liu, Y.C. et al. 2014. Science signaling. 7: ra117.

PMID: # 23650387  Coles, GL. et al. 2013. Proceedings of the National Academy of Sciences of the United States of America. 110: E1898-905.

PMID: # 23069989  Bertacchi, M. et al. 2013. Cell. Mol. Life Sci. 70: 1095-111.

Citations 1 to 10 of 14 total
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Rated 5 out of 5 by from Singh Singh, N. et al. (PubMed 25540129) found that a single treatment of newborn trisomic mice with SAG, a potent agonist of Hedgehog (Hh) signaling, normalized cerebellar morphology and restored some cognitive deficits, suggesting a possible therapeutic application of SAG for treating the cognitive impairments of Down syndrome. -SCBT Publication Review
Date published: 2015-02-21
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