Safingol CAS: 15639-50-6
MF: C18H39NO2
MW: 301.5
A lyso-sphingolipid protein kinase C inhibitor.

Safingol (CAS 15639-50-6)

Safingol | CAS 15639-50-6 is rated 5.0 out of 5 by 1.
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Alternate Names: L-threo-Dihydrosphingosine
Application: Safingol is a lyso-sphingolipid protein kinase C inhibitor
CAS Number: 15639-50-6
Molecular Weight: 301.5
Molecular Formula: C18H39NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Safingol is a lyso-sphingolipid PKC (protein kinase C ) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Safingol inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 μM and 31μM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 μM). Safingol enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC) in gastric cancer cells by promoting drug-induced apoptosis. Safingol is an inhibitor of SphK (Sphingosine kinase).


References

Kedderis, L.B., et al. 1995. Fundam. Appl. Toxicol. 25, 201. Sachs, C.W., et al. 1995. J. Biol. Chem. 270, 26639. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87,1394

Physical State :
Solid
Solubility :
Soluble in chloroform, water (partly miscible), DMSO (~2 mg/ml), DMF (~10 mg/ml), ethanol, and methanol.
Storage :
Store at -20° C
Melting Point :
106.8-108.7° C
Boiling Point :
>300° C
Density :
~0.9 g/cm3 (Predicted)
Refractive Index :
n20D 1.48 (Predicted)
IC50 :
enzymatic activity: IC50 = 37.5 µM; 3H-phorbol dibutyrate binding of purified rat brain PKC: IC50 = 31 µM; PKCα in MCF-7 DOXR cells: IC50 = 40 µM (human)
pK Values :
pKa: 12.57, pKb: 8.57
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00792847
SMILES :
CCCCCCCCCCCCCCC[[email protected]@H]([[email protected]](CO)N)O

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Certificate of Analysis

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Safingol (CAS 15639-50-6)  Product Citations

See how others have used Safingol (CAS 15639-50-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24970481  Hsu, YH. et al. 2014. Cancer Res. 74: 4822-35.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Hamada et al Hamada et al. (PubMed ID 24549171) found that Safingol increased intracellular H2O2 levels and had an apoptotic effect in squamous cell carcinoma cells. -SCBT Publication Review
Date published: 2015-06-26
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