Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Sab is a Src homology 3 domain (SH3) binding protein that preferentially associates with Bruton's tyrosine kinase, Btk, over other related tyrosine kinases. Btk, together with Itk, Tec, Txk and Bmx, is a member of a family of cytoplasmic tyrosine kinases (the Btk/Tec family). Btk is a B cell specific kinase that is crucial for human and murine B cell development, and its deficiency causes human X-linked agammaglobulinemia and murine X-linked immunodeficiency. Sab serves as a negative regulator of Btk kinase activity and Sab binding to Btk reduces the phosphorylation of Btk substrates and also inhibits Btk-induced auto-phosphorylation in B cells. The SH3 domain of Sab directly binds to the SH3 domain of Btk and this interaction is essential for the reg-ulatory activity of Sab. Sab is more broadly expressed than Btk, suggesting that Sab may target additional protein kinases that are specific to various tissues.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.