S14-95 is a potent inhibitor of cytokine-induced activation of STAT1α which leads to the inhibition of inducible expression of proinflammatory enzymes including COX-2 and iNOS (NOS II), as well as cytokines such as TNF-α.
G. Erkel, et al.; J. Antibiot. 56, 337 (2003).
Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003).
Soluble in methanol.
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Erkel et alErkel et al. (PubMed ID 12817806) found that S14-95 blocked phosphorylation of the STAT1alpha transcription factor in Penicillium species. -SCBT Publication Review
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