S14-95An inhibitor of cytokine-induced activation of STAT1α

S14-95

S14-95 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of cytokine-induced activation of STAT1α
Purity: ≥95%
Molecular Weight: 450.57
Molecular Formula: C28H34O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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S14-95 is a potent inhibitor of cytokine-induced activation of STAT1α which leads to the inhibition of inducible expression of proinflammatory enzymes including COX-2 and iNOS (NOS II), as well as cytokines such as TNF-α.


References

G. Erkel, et al.; J. Antibiot. 56, 337 (2003). Y. Yao, et al.; Mol. Pharmacol. 63, 383 (2003).

Appearance :
Powder
Physical State :
Solid
Derived From :
Penicillium sp.
Solubility :
Soluble in methanol.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57781179
SMILES :
CC(=O)OC1CCC2(C(C1(C)C)CCC3(C2CC4=C(O3)C=C(OC4=O)C5=CC=CC=C5)C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Erkel et al Erkel et al. (PubMed ID 12817806) found that S14-95 blocked phosphorylation of the STAT1alpha transcription factor in Penicillium species. -SCBT Publication Review
Date published: 2015-07-01
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