(+)-(S)-Tylophorine

(+)-(S)-Tylophorine (CAS 482-20-2)

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Synonym: (S)-9,11,12,13,13a,14-Hexahydro-2,3,6,7-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline
Application: An immunosuppressant and inflammation inhibitor
CAS Number: 482-20-2
Molecular Weight: 393.48
Molecular Formula: C24H27NO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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(+)-(S)-Tylophorine is a a major alkaloid of Tylophora indica. It is an immunosuppressant that inhibits inflammation. In tumor cells, (+)-(S)-Tylophorine has shown antiproliferative activity and induction of apoptosis.


References

1. Gopalakrishnan, C., et al., 1979. Pharmacological investigations of tylophorine, the major alkaloid of Tylophora indica. The Indian journal of medical research. 69(): 513-20. PMID: 447392
2. Raina, V., et al., 1980. The responsiveness of leukocyte adenyl cyclase to tylophorine in asthmatic subjects. Biochemical and biophysical research communications. 94(4): 1074-7. PMID: 7396949
3. Gopalakrishnan, C., et al., 1980. Effect of tylophorine, a major alkaloid of Tylophora indica, on immunopathological and inflammatory reactions. The Indian journal of medical research. 71(): 940-8. PMID: 7419261
4. Comins, Daniel L.., et al., 1997. Enantiopure N-Acyldihydropyridones as Synthetic Intermediates: Asymmetric Synthesis of (-)-Septicine and (-)-Tylophorine. The Journal of organic chemistry. 62(21): 7435-7438. PMID: 11671861
5. Gao, Wenli., et al., 2004. Novel mode of action of tylophorine analogs as antitumor compounds. Cancer research. 64(2): 678-88. PMID: 14744785

Physical State :
Solid
Solubility :
Soluble in chloroform.
Storage :
Store at 4° C
Melting Point :
211.62° C (Predicted)
Boiling Point :
~559.9° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1544, Class 6.1, Packing group III
PubChem CID :
92114
SMILES :
COC1=C(C=C2C(=C1)C3=C(CN4CCC[C@H]4C3)C5=CC(=C(C=C52)OC)OC)OC

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Certificate of Analysis

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(+)-(S)-Tylophorine  Product Citations

See how others have used (+)-(S)-Tylophorine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31078367  Joa, H. et al. 2019. Phytomedicine. 152938.

Citations 1 to 1 of 1 total
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