Timolol Maleate is a adrenergic receptor antagonist selective for β1-AR. Adrenergic receptors, or adrenoreceptors, are G-protein coupled receptors involved in a variety of sympathetic nervous system processes. Antagonists such as Timolol Maleate that affect the β adrenoreceptors are commonly known as beta blockers that decrease cardiac output.
Hall RA, Robson RD, Share NN. Arch Int Pharmacodyn Ther. 213:251-63 (1975). Feghali JG, Kaufman PL, Radius RL et al. Acta Ophthalmol (Copenh). 66:180-6 (1988).
Soluble in water (115), alcohol (121), chloroform (140), and DMSO.
Store at room temperature
202-203° C (lit.)
n20D ~1.55 (Predicted)
[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
Plasmodium falciparum W2: IC50 = 12.59
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
NagaiNagai, N. et al. (PubMed 26136174) reported a decrease in corneal damage due to benzalkonium chloride by the addition of mannitol into Timolol Maleate eye drops. -SCBT Publication Review
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