(S)-Timolol MaleateCAS: 26921-17-5
MF: C13H24N4O3S•C4H4O4
MW: 432.49
A selective β1-AR receptor antagonist.

(S)-Timolol Maleate (CAS 26921-17-5)

(S)-Timolol Maleate | CAS 26921-17-5 is rated 5.0 out of 5 by 1.
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Synonym: S-(-)-1-(t-Butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate salt
Application: A selective β1-AR receptor antagonist
CAS Number: 26921-17-5
Purity: ≥98%
Molecular Weight: 432.49
Molecular Formula: C13H24N4O3S•C4H4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Timolol Maleate is a adrenergic receptor antagonist selective for β1-AR. Adrenergic receptors, or adrenoreceptors, are G-protein coupled receptors involved in a variety of sympathetic nervous system processes. Antagonists such as Timolol Maleate that affect the β adrenoreceptors are commonly known as beta blockers that decrease cardiac output.


References

Hall RA, Robson RD, Share NN. Arch Int Pharmacodyn Ther. 213:251-63 (1975). Feghali JG, Kaufman PL, Radius RL et al. Acta Ophthalmol (Copenh). 66:180-6 (1988).

Physical State :
Solid
Solubility :
Soluble in water (115), alcohol (121), chloroform (140), and DMSO.
Storage :
Store at room temperature
Melting Point :
202-203° C (lit.)
Refractive Index :
n20D ~1.55 (Predicted)
Optical Activity :
[α]25/D -5.4°, c = 4.9 in 1 M HCl(lit.)
IC50 :
Plasmodium falciparum W2: IC50 = 12.59
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UA8475000
PubChem CID :
16220042
Merck Index :
14: 9444
MDL Number :
MFCD00058356
EC Number :
248-111-5
SMILES :
CC(C)(C)NC[[email protected]@H](COC1=NSN=C1N2CCOCC2)O.C(=C/C(=O)O)\\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. This chemical is soluble in water, alcohol, DMSO, and choloroform. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-25
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Rated 5 out of 5 by from Nagai Nagai, N. et al. (PubMed 26136174) reported a decrease in corneal damage due to benzalkonium chloride by the addition of mannitol into Timolol Maleate eye drops. -SCBT Publication Review
Date published: 2015-07-18
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