S(-)-Propranolol hydrochlorideCAS: 4199-10-4
MF: C16H21NO2•HCl
MW: 295.80
A β-adrenergic receptor antagonist.

S(-)-Propranolol hydrochloride (CAS 4199-10-4)

S(-)-Propranolol hydrochloride | CAS 4199-10-4 is rated 5.0 out of 5 by 1.
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Synonym: (S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
Application: A β-adrenergic receptor antagonist
CAS Number: 4199-10-4
Purity: ≥98%
Molecular Weight: 295.80
Molecular Formula: C16H21NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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S(-)-Propranolol • HCl is a small molecule β-adrenergic receptor antagonist and the active isomer of (±)-Propranolol preparations. S(-)-Propranolol • HCl blocks the binding of epinephrine, norepinephrine, and other endogenous catecholamines to the β-adrenergic receptor, impeding increases in cardiac flow velocity and general stimulation of the sympathetic nervous system signaled by association of these molecules to the β-adrenergic receptor. In addition to blockade of agonist binding, antagonism of the β-adrenergic receptor by S(-)-Propranolol • HCl produces negative chronotropic and inotropic action, effectively dampening the force and rate of cardiac contraction. These negative chronotropic and inotropic effects correlate to a demonstrated suppression of adrenaline-induced cardiac arrhythmia by S(-)-Propranolol • HCl. Suppression of β-adrenergic receptor activation by S(-)-Propranolol • HCl has been widely exploited in counteracting situations sensitive to heightened cardiac activity including hypertension, angina pectoris, and cardiac ischemia.


References

1. Howe, R. and Shanks, R.G. 1966. Nature. 210: 1336-1338. PMID: 5963764
2. Mehvar, R. and Brocks, D.R. 2001. J Pharm Pharm Sci. 4: 185-200. PMID: 11466176

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), ethanol (10 mg/ml), DMSO (<14.5 mg/ml), and chloroform (slightly soluble). Insoluble in ether, benzene, and ethyl acetate.
Storage :
Store at 4° C
Melting Point :
193-196° C (lit.)
Boiling Point :
434.9° C at 760 mmHg (Predicted)
Optical Activity :
α20D -28.3°, c = 1 in ethanol; α20D -25.5°, c = 1.0 in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
165193
MDL Number :
MFCD00064547
EC Number :
224-096-0
Beilstein Registry :
3574966
SMILES :
CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Albi ana Albi ana, V. et al. (PubMed 26394686) reported that the -adrenergic receptor antagonist S(-)-Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients. -SCBT Publication Review
Date published: 2015-04-29
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