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S-Methyl-L thiocitrulline Dihydrochloride is a potent cell-permeable inhibitor of NOS1 (nNOS) (IC50 = 300 nM), and a fairly potent inhibitor of NOS3 (eNOS) (IC50 = 5.4 μM). S-Methyl-L thiocitrulline has been shown to provide neuroprotection in mice, thought to be accomplished by blocking NO generation, which could otherwise combine with free radicals producing tissue damaging peroxynitrites. S-Methyl-L thiocitrulline, Dihydrochloride is a poteintial but less potent inhibitor of NOS2 (iNOS).
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2. Colado, M.I., et al. 2001. Br. J. Pharmacol. 134: 1711-1723. PMID: 11739248
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