S-Methyl-L thiocitrulline, DihydrochlorideA potent inhibitor of NOS1 and NOS3

S-Methyl-L thiocitrulline, Dihydrochloride (CAS 209589-59-3)

S-Methyl-L thiocitrulline, Dihydrochloride | CAS 209589-59-3 is rated 5.0 out of 5 by 1.
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Application: A potent inhibitor of NOS1 and NOS3
CAS Number: 209589-59-3
Molecular Weight: 278.2
Molecular Formula: C7H15N3O2S•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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S-Methyl-L thiocitrulline Dihydrochloride is a potent cell-permeable inhibitor of NOS1 (nNOS) (IC50 = 300 nM), and a fairly potent inhibitor of NOS3 (eNOS) (IC50 = 5.4 μM). S-Methyl-L thiocitrulline has been shown to provide neuroprotection in mice, thought to be accomplished by blocking NO generation, which could otherwise combine with free radicals producing tissue damaging peroxynitrites. S-Methyl-L thiocitrulline, Dihydrochloride is a poteintial but less potent inhibitor of NOS2 (iNOS).


References

1. Bazzett, T., et al. 1997. Brain Res. 775: 229-232. PMID: 9439850
2. Colado, M.I., et al. 2001. Br. J. Pharmacol. 134: 1711-1723. PMID: 11739248

Physical State :
Solid
Solubility :
Soluble in cold water (easily soluble), methanol, ethanol (75 mg/ml), DMSO (20 mg/ml), DMF (14 mg/ml), and PBS (pH 7.2) (~25 mg/ml).
Storage :
Store at 4° C
Melting Point :
118-120° C
Refractive Index :
n20D ~1.59 (Predicted)
IC50 :
NOS1: IC50 = 300 nM; NOS2: IC50 = 60 nM (human); NOS3: IC50 = 5.4 µM
Ki Data :
nNOS: Ki= 1.2 nM; eNOS: Ki= 11 nM; iNOS: Ki= 40 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2733508
SMILES :
CSC(=NCCC[C@@H](C(=O)O)N)N.Cl.Cl

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Certificate of Analysis

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Rated 5 out of 5 by from Wang Y; et al Wang Y; et al. (PubMed ID: 26115836) determined that S-Methyl-L thiocitrulline, Dihydrochloride, a nNOS inhibitor, greatly increased L-type Ca(2+) channel activity in rat myocytes. -SCBT Publication Review
Date published: 2015-01-23
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