S-Methyl-L thiocitrulline Dihydrochloride is a potent cell-permeable inhibitor of NOS1 (nNOS) (IC50 = 300 nM), and a fairly potent inhibitor of NOS3 (eNOS) (IC50 = 5.4 μM). S-Methyl-L thiocitrulline has been shown to provide neuroprotection in mice, thought to be accomplished by blocking NO generation, which could otherwise combine with free radicals producing tissue damaging peroxynitrites. S-Methyl-L thiocitrulline, Dihydrochloride is a poteintial but less potent inhibitor of NOS2 (iNOS).
1. Bazzett, T., et al. 1997. Brain Res. 775: 229-232. PMID: 9439850 2. Colado, M.I., et al. 2001. Br. J. Pharmacol. 134: 1711-1723. PMID: 11739248
Soluble in cold water (easily soluble), methanol, ethanol (75 mg/ml), DMSO (20 mg/ml), DMF (14 mg/ml), and PBS (pH 7.2) (~25 mg/ml).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Wang Y; et alWang Y; et al. (PubMed ID: 26115836) determined that S-Methyl-L thiocitrulline, Dihydrochloride, a nNOS inhibitor, greatly increased L-type Ca(2+) channel activity in rat myocytes. -SCBT Publication Review
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