S-Methyl-L thiocitrulline Dihydrochloride is a potent cell-permeable inhibitor of NOS1 (nNOS) (IC50 = 300 nM), and a fairly potent inhibitor of NOS3 (eNOS) (IC50 = 5.4 μM). S-Methyl-L thiocitrulline has been shown to provide neuroprotection in mice, thought to be accomplished by blocking NO generation, which could otherwise combine with free radicals producing tissue damaging peroxynitrites. S-Methyl-L thiocitrulline, Dihydrochloride is a poteintial but less potent inhibitor of NOS2 (iNOS).
1. Bazzett, T., et al. 1997. Brain Res. 775: 229-232. PMID: 9439850 2. Colado, M.I., et al. 2001. Br. J. Pharmacol. 134: 1711-1723. PMID: 11739248
Soluble in cold water (easily soluble), methanol, ethanol (75 mg/ml), DMSO (20 mg/ml), DMF (14 mg/ml), and PBS (pH 7.2) (~25 mg/ml).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 95ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Wang Y; et alWang Y; et al. (PubMed ID: 26115836) determined that S-Methyl-L thiocitrulline, Dihydrochloride, a nNOS inhibitor, greatly increased L-type Ca(2+) channel activity in rat myocytes. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.