(S)-Mephenytoin CAS: 70989-04-7
MF: C12H14N2O2
MW: 218.25
A substrate for assaying CYP2C19 polymorphism.

(S)-Mephenytoin (CAS 70989-04-7)

(S)-Mephenytoin | CAS 70989-04-7 is rated 5.0 out of 5 by 1.
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Alternate Names: (S)-5-Ethyl-3-methyl-5-phenylhydantoin
Application: (S)-Mephenytoin is a substrate for assaying CYP2C19 polymorphism
CAS Number: 70989-04-7
Purity: ≥98%
Molecular Weight: 218.25
Molecular Formula: C12H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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(S)-Mephenytoin is a hydantoin small molecule, originally discovered and implemented for its anticonvulsant effects. Individuals present a variable ability to perform hydroxylation of (S)-Mephenytoin at the 4'-position associated with polymorphism in CYP2C19, an oxidase in the cytochrome P-450 system. The poor metabolizer phenotype, those incapable of metabolizing (S)-Mephenytoin by 4'-hydroxylation, also show a reduced ability to clear other pharmaceuticals and xenobiotics, and this (S)-Mephenytoin metabolism experiment has been used to explore the implications of this common phenotypic condition in drug design and toxicity expectations. (S)-Mephenytoin is a substrate of CYP2B6 and CYP2C19.


References

1. Guengerich, F.P. 1989. Trends Pharmacol. Sci. 10: 107-109. PMID: 2688217
2. Meyer, U.A. 1990. Fundam Clin Pharmacol. 4: 595-615. PMID: 1982880
3. de Morais, S.M., et al. 1995. Clin. Pharmacol. Ther. 58: 404-411. PMID: 7586932
4. Huang, S., et al. 1997. Se Pu. 15: 408-410. PMID: 15739491
5. Oda, A., et al. 2004. Pharm. Res. 21: 2270-2278. PMID: 15648259
6. Di Marco, A., et al. 2007. Drug Metab. Dispos. 35: 1737-1743. PMID: 17600081
7. Lee, S.J., et al. 2009. Drug Metab. Dispos. 37: 2262-2269. PMID: 19661214

Usage :
(S)-Mephenytoin is slightly soluble in DMSO, Ethanol and Methanol.
Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml), DMSO (50 mg/ml), acetone, chloroform, and Ethyl Acetate.
Storage :
Store at room temperature
Melting Point :
135-138° C
Boiling Point :
429.83° C (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
pK Values :
pKa: 8.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
PubChem CID :
MDL Number :
MFCD00270025
SMILES :
CC[[email protected]@]1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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(S)-Mephenytoin (CAS 70989-04-7)  Product Citations

See how others have used (S)-Mephenytoin (CAS 70989-04-7). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 12 total

PMID: # 29320899  Krasulova, K.|Dvorak, Z.|Anzenbacher, P.| et al. 2019. Xenobiotica. 49: 36-42.

PMID: # 30010032  Cheng, HX. et al. 2018. Eur J Pharm Sci. 123: 241-248.

PMID: # 28056947  Lu, Y.|Xie, T.|Zhang, Y.|Zhou, F.|Ruan, J.|Zhu, W.|Zhu, H.|Feng, Z.|Zhou, X.| et al. 2017. BMC Complement Altern Med. 17: 15.

PMID: # 29099769  Krasulova, K. et al. 2017. Molecules. 22:

PMID: # 27312150  Kopečná-Zapletalová, M. et al. 2016. Xenobiotica. 1-8.

PMID: # 27519550  Cherian, MT. et al. 2016. Drug Metab. Dispos. 44: 1759-1770.

PMID: # 27732883  Štěpánková, M. et al. 2016. Toxicol. Lett. 262: 173-186.

PMID: # 26338061  Krasulova, K. et al. 2016. Xenobiotica. 46: 315-24.

PMID: # 25249693  Wu, J. et al. 2014. Drug Metab. Dispos. 42: 2058-67.

PMID: # 23241944  Hu, Y. et al. 2013. Pharmacogenet. Genomics. 23: 78-83.

Citations 1 to 10 of 12 total

What is the storage temperature after reconstitution in DMSO please ?

Asked by: Floriansimon
Thanks for your question. The product can be stored at room temperature after reconstitution in DMSO. Please contact technical service if any further support is required.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-07

Is the compound cell biology grade?

Asked by: two2igm05
We do not specify a grade for this produtct.
Answered by: Chemical Support 4
Date published: 2017-02-25
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Rated 5 out of 5 by from Various publications cite the use of (S) Various publications cite the use of (S)-Mephenytoin as a substrate for assaying CYP2C19 polymorphism. -SCBT Publication Review
Date published: 2015-01-23
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