(S)-Ibuprofen is the active enantiomer of ibuprofen. (S)-Ibuprofen inhibits Cox-1 and Cox-2 with comparable potency (ID50 = 8.9-14 μM and 7.2-8.2 μM, respectively). (S)-Ibuprofen acts as a non-steroidal analgesic and antiinflammatory agent. This compound's inhibition of Cox-1 and Cox-2 and activation of PPARα and PPARγ isoforms may be responsible for its pharmacological effects.
1. Mehvar, R. and Jamali, F. 1988. Pharm. Res. 5: 76-79. PMID: 3247296 2. Meade, E.A. et al. 1993. J. Biol. Chem. 268: 6610-6614. PMID: 8454631 3. Jaradat, M.S. et al. 2001. Biochem. Pharmacol. 62: 1587-1595. PMID: 11755111
Soluble in DMSO (100 mM), ethanol (100 mM), dichloromethane, ethyl acetate, and methanol. Insoluble in water.
Store at room temperature
49-53° C (lit.)
~319.6° C at 760 mmHg (Predicted)
~1.0 g/cm3 (Predicted)
n20D 1.52 (Predicted)
α20/D +59°, c = 2 in ethanol; α20/D +61.7°, c = 0.6 in Methanol
Rated 5 out of
Various publications cite (S)Various publications cite (S)-Ibuprofen as the active enantiomer of ibuprofen. (S)-Ibuprofen inhibits Cox-1 and Cox-2 with comparable potency (ID50 = 8.9-14 M and 7.2-8.2 M, respectively). -SCBT Publication Review
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