(S)-ESBA hydrochlorideA mouse and rat KAT II inhibitor

(S)-ESBA hydrochloride

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Application: A mouse and rat KAT II inhibitor
Purity: ≥98%
Molecular Weight: 321.78
Molecular Formula: C12H15NO5S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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(S)-ESBA HCl is a potent and selective mouse/rat kynurenine aminotransferase II (KAT II) inhibitor.


References

1. Pellicciari, Roberto., et al., 2006. Modulators of the kynurenine pathway of tryptophan metabolism: synthesis and preliminary biological evaluation of (S)-4-(ethylsulfonyl)benzoylalanine, a potent and selective kynurenine aminotransferase II (KAT II) inhibitor. ChemMedChem. 1(5): 528-31. PMID: 16892388
2. Schwarcz, Robert., et al., 2007. Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid? Schizophrenia bulletin. 33(3): 652-3. PMID: 17434932
3. Pellicciari, Roberto., et al., 2008. Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA. ChemMedChem. 3(8): 1199-202. PMID: 18537204
4. Rossi, Franca., et al., 2008. Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis. Current opinion in structural biology. 18(6): 748-55. PMID: 18950711
5. Rossi, Franca., et al., 2008. Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis. Current opinion in structural biology. 18(6): 748-55. PMID: 18950711
6. Amori, L., et al., 2009. Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 159(1): 196-203. PMID: 19138730

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, and DMSO.
Storage :
Store at -20° C
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
KAT II: IC50 = 6.1 µM (mouse/rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57347503
SMILES :
CCS(=O)(=O)C1=CC=C(C=C1)C(=O)C[C@@H](C(=O)O)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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(S)-ESBA hydrochloride  Product Citations

See how others have used (S)-ESBA hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27367665  Nematollahi, A. et al. 2016. Molecules. 21:

Citations 1 to 1 of 1 total
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