(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid is an active enantiomer of AMPA ((R,S)-AMPA) that induces apoptotic cell death in cortical neurons. Does not exhibit any affinity for NMDA receptors. (S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid is an activator of GluR.
John, C.A., et al. 1999. Neurosci. Lett. 268, 9. Bang-Andersen, B., et al. 1997. J. Med. Chem. 40, 2831. Lauridsen, J., et al. 1985. J. Med. Chem. 28, 668. Hansen, J.J., et al. 1983. J. Med. Chem. 26, 901.
Soluble in water (100 mM), 1 M HCl (50 mg/ml), and dilute aqueous base.
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