Molecular structure of S-(5′-Adenosyl)-L-Methionine Iodide, CAS Number: 3493-13-8
S-(5′-Adenosyl)-L-Methionine Iodide (CAS 3493-13-8)
Alternate Names:
AdoMet; SAM
Application:
S-(5′-Adenosyl)-L-Methionine Iodide is cofactor for enzyme-catalyzed methylations
CAS Number:
3493-13-8
Purity:
≥80%
Molecular Weight:
526.35
Molecular Formula:
C15H23IN6O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-(5′-Adenosyl)-L-Methionine Iodide is methyl donor and cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis. Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
S-(5′-Adenosyl)-L-Methionine Iodide (CAS 3493-13-8) References
- Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate. | Coughlin, JE., et al. 2012. Drug Metab Dispos. 40: 970-81. PMID: 22328581
- Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid Magnoflorine in Opium Poppy. | Morris, JS. and Facchini, PJ. 2016. J Biol Chem. 291: 23416-23427. PMID: 27634038
- Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering. | Xing, L., et al. 2018. EMBO J. 37: PMID: 30150325
- Indoleacetate decarboxylase is a glycyl radical enzyme catalysing the formation of malodorant skatole. | Liu, D., et al. 2018. Nat Commun. 9: 4224. PMID: 30310076
- A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase. | Stoddard, CI., et al. 2019. Mol Cell. 73: 73-83.e6. PMID: 30415948
- Non-peptidyl small molecule, adenosine, 5'-Se-methyl-5'-seleno-, 2',3'-diacetate, activates insulin receptor and attenuates hyperglycemia in type 2 diabetic Leprdb/db mice. | Lan, ZJ., et al. 2020. Cell Mol Life Sci. 77: 1623-1643. PMID: 31378829
- Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. | Zhu, J., et al. 2019. Cell Metab. 30: 865-876.e5. PMID: 31607565
- Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma. | Michealraj, KA., et al. 2020. Cell. 181: 1329-1345.e24. PMID: 32445698
- Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. | Bian, Y., et al. 2020. Nature. 585: 277-282. PMID: 32879489
- Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity. | Premasiri, AS., et al. 2020. Front Pharmacol. 11: 569661. PMID: 33013410
- PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. | Huang, T., et al. 2021. Mol Cell. 81: 1276-1291.e9. PMID: 33539787
- Emission of floral volatiles is facilitated by cell-wall non-specific lipid transfer proteins. | Liao, P., et al. 2023. Nat Commun. 14: 330. PMID: 36658137
- PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism. | Sun, M., et al. 2023. Acta Pharm Sin B. 13: 157-173. PMID: 36815049
- A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination. | Qiang, L., et al. 2023. Nat Commun. 14: 1430. PMID: 36932056
- Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells. | Pandit, M., et al. 2023. Nat Commun. 14: 2593. PMID: 37147330
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(5′-Adenosyl)-L-Methionine Iodide, 5 mg | sc-281510 | 5 mg | $89.00 |