S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)CAS: 38048-32-7
MF: C17H17N5O6S
MW: 419.4
An inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties.

S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) (CAS 38048-32-7)

S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) | CAS 38048-32-7 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties
CAS Number: 38048-32-7
Purity: ≥98%
Molecular Weight: 419.4
Molecular Formula: C17H17N5O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR) is a small molecule inhibitor of equilibrative nucleoside transporter (ENT) proteins. These transport proteins are described in relation to their sensitivity to NBMPR, designated as either es (NBMPR-sensitive) or ei (NBMPR-insensitive). They provide good research tools anticancer, antiviral, cardioprotective, and neuroprotective agents. Inhibition of ENT1 by NBMPR blocks the uptake and transport of adenosine, which affects the regulation of extracellular adenosine levels and the cardiac system signaling associated with adenosine.


References

1. Krug, E.C., et al. 1989. J. Biol. Chem. 264: 10601-10607. PMID: 2732241
2. Griffiths, M., et al. 1997. Biochem. J. 328: 739-743. PMID: 9396714
3. Yao, S.Y., et al. 1997. J. Biol. Chem. 272: 28423-18430. PMID: 9353301
4. Zhu, Z., et al. 2003. J. Med. Chem. 46: 831-837. PMID: 12593662
5. Baldwin, S.A., et al. 2005. J. Biol. Chem. 280: 15880-15887. PMID: 15701636
6. Barnes, K., et al. 2006. Circ. Res. 99: 510-519. PMID: 16873718

Usage :
Store stock solutions at -20°C or below and used within 1 month.
Physical State :
Solid
Solubility :
Soluble in water (Partly miscible), DMSO, methanol, and DMF. Insoluble in hexane.
Storage :
Store at -20° C
Melting Point :
187-190° C (lit.)
IC50 :
Potent adenosine uptake and nucleoside transport : IC50 = 4.6 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UO9025000
PubChem CID :
65407
MDL Number :
MFCD00005745
EC Number :
253-753-4
SMILES :
C1=CC(=CC=C1CSC2=NC=NC3=C2N=CN3[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Shimada Shimada, T. et al. (PubMed 26037416) investigated the gemcitabine (GEM) uptake in rat and human isolated heptaocytes. GEM uptake involved high- and low-affinity saturable components, however this uptake was inhibited by NBMPR, an inhibitor of ENTs with potential anticancer, cardio-, and neuro- protective properties. -SCBT Publication Review
Date published: 2015-05-03
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