(S)-3-HydroxyphenylglycineAn agonist at group I metabotrobic glutamate receptors

(S)-3-Hydroxyphenylglycine (CAS 71301-82-1)

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Synonym: (S)-3H-PG
Application: An agonist at group I metabotrobic glutamate receptors
CAS Number: 71301-82-1
Purity: ≥99%
Molecular Weight: 167.16
Molecular Formula: C8H9NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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(S)-3-Hydroxyphenylglycine is an agonist at group I metabotropic glutamate receptors (mGluR) having no effect at mGluR-2 or mGluR-4.


References

1. Birse et al (1993) Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience 52 481. 2. Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J.Neurosci. 14 3370.

Physical State :
Solid
Solubility :
Soluble in water (50 mM), phosphate buffered saline (50 mM), 1eq NaOH (100 mM), and 1eq HCl (100 mM).
Storage :
Desiccate at room temperature
Melting Point :
238.81° C (Predicted)
Boiling Point :
382.62° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20/D +156°, c = 0.5
IC50 :
Metabotropic glutamate receptor 1: EC5050 = 68000 nM (human)
pK Values :
pKa: 1.85, pKb: 10.36
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6604712
SMILES :
C1=CC(=CC(=C1)O)[C@@H](C(=O)O)N

Download SDS (MSDS)

Certificate of Analysis

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