S-(+)-Niguldipine hydrochloride is an L-type calcium channel protein inhibitor and α1A-AR adrenoceptor antagonist. S-(+)-Niguldipine hydrochloride is the more active enantiomer relative to (R)-(-)-Niguldipine hydrochloride (sc-203676).
1. Boer, R., et al. 1989. Eur. J. Pharmacol. 172: 131-145. PMID: 2548881 2. Graziadei, I., et al. 1989. Eur. J. Pharmacol. 172: 329 -337. PMID: 2555206 3. Klockner, U., et al. 1989. Arzneimittelforschung. 39: 120-126. PMID: 2541731 4. Robinson, J.P., et al. 1990. Br. J. Pharmacol. 100: 3-4. PMID: 2164859
Soluble in DMSO (100 mM), ethanol (100 mM), and methanol (8 mg/ml). Insoluble in water, and dilute aqueous acid .
Desiccate at -20° C
n20D 1.59 (Predicted)
α22/D +14.62°, c = 0.13 in methanol; α20/D +14°, c = 1 in methanol
P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells : IC50 = 707.95 nM
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