S-(+)-Niguldipine hydrochlorideA calcium channel protein inhibitor

S-(+)-Niguldipine hydrochloride (CAS 113165-32-5)

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Synonym: S(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride
Application: A calcium channel protein inhibitor
CAS Number: 113165-32-5
Molecular Weight: 646.18
Molecular Formula: C36H39N3O6•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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S-(+)-Niguldipine hydrochloride is an L-type calcium channel protein inhibitor and α1A-AR adrenoceptor antagonist. S-(+)-Niguldipine hydrochloride is the more active enantiomer relative to (R)-(-)-Niguldipine hydrochloride (sc-203676).


References

1. Boer, R., et al. 1989. Eur. J. Pharmacol. 172: 131-145. PMID: 2548881
2. Graziadei, I., et al. 1989. Eur. J. Pharmacol. 172: 329 -337. PMID: 2555206
3. Klockner, U., et al. 1989. Arzneimittelforschung. 39: 120-126. PMID: 2541731
4. Robinson, J.P., et al. 1990. Br. J. Pharmacol. 100: 3-4. PMID: 2164859

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (100 mM), and methanol (8 mg/ml). Insoluble in water, and dilute aqueous acid .
Storage :
Desiccate at -20° C
Melting Point :
135-137° C
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α22/D +14.62°, c = 0.13 in methanol; α20/D +14°, c = 1 in methanol
IC50 :
P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells : IC50 = 707.95 nM
Ki Data :
α1A-AR: Ki= 0.16 nM (human); α1-1a adrenergic receptor: Ki= 0.38 nM (bovine); α1-1a adrenergic receptor: Ki= 6.38 nM (rat); Voltage-gated L-type calcium channel α1-1C subunit: Ki= 9 nM (rat); α1B-AR: Ki= 25.01 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219720
MDL Number :
MFCD00873564
SMILES :
CC1=C([C@@H](C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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